Clinical trial · Observational
Selective Rather Than Routine Histopathological Examination Following Appendectomy and Cholecystectomy
Selective Rather Than Routine Histopathological Examination Following Appendectomy and Cholecystectomy; the FANCY Study.
NCT03510923CI-TRIAL-00077724FANCYcompletedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The FANCY study will investigate whether a selective policy of histopathological examination of appendices and gallbladders based on the intraoperative findings of the surgeon is safe and cost-effective.
Conditions
Conditions (6)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Appendectomy | — | UNRESOLVED | — |
| Appendiceal Neoplasms | Appendix Neoplasm | ALIAS | 0.90 |
| Appendix | — | UNRESOLVED | — |
| Cholecystectomy | — | UNRESOLVED | — |
| Gallbladder | — | UNRESOLVED | — |
| Gallbladder Neoplasms | Gallbladder Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Inspection and palpation of the appendix | Other | — | UNRESOLVED |
| Inspection and palpation of the gallbladder | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Patients who underwent an appendectomy
- description
- Patients of all ages who underwent an appendectomy in the elective or non-elective setting.
- interventionNames
- Other: Inspection and palpation of the appendix
- label
- Patients who underwent a cholecystectomy
- description
- Patients of all ages who underwent a cholecystectomy in the elective or non-elective setting.
- interventionNames
- Other: Inspection and palpation of the gallbladder
Primary outcomes (2)
- measure
- Unnoticed neoplasms requiring additional therapy benefitting the patient
- timeFrame
- 3 months
- description
- Number of patients per 1000 examined appendices/gallbladders with a neoplasm requiring additional therapy benefitting the patient that would have been unnoticed in the policy of selective histopathological examination.
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Patients scheduled to undergo an appendectomy or cholecystectomy in the elective or non-elective setting. Exclusion Criteria: * Primary indication for surgery: strong suspicion or proven malignancy in the appendix or gallbladder. * Appendix or gallbladder removed as part of more extensive surgery, so-called incidental appendectomies or cholecystectomies. * Patients included in the ACCURE trial (effect of appendectomy on ulcerative colitis). * The presence of a gallbladder polyp of \>10 mm on preoperative imaging.
References
Publications (1)
- DERIVEDBastiaenen VP, Corten BJ, de Savornin Lohman EA, de Jonge J, Kraima AC, Swank HA, van Vliet JL, van Acker GJ, van Geloven AA, In 't Hof KH, Koens L, de Reuver PR, van Rossem CC, Slooter GD, Tanis PJ, Terpstra V, Dijkgraaf MG, Bemelman WA. Safety and cost analysis of selective histopathological examination following appendicectomy and cholecystectomy (FANCY study): protocol and statistical analysis plan of a prospective observational multicentre study. BMJ Open. 2019 Dec 23;9(12):e035912. doi: 10.1136/bmjopen-2019-035912. PMID 31874901