Clinical trial · Interventional
Effect of Polyglycolic Acid Mesh (Neoveil) in Thyroid Cancer Surgery
Effect of Polyglycolic Acid Mesh (Neoveil) for Reducing Drain Amount and Chyle Leakage After Thyroid Cancer Surgery: A Prospective, Randomized Controlled Study
NCT03510143CI-TRIAL-00032702unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study is a randomized controlled study to investigate the effect of "Polyglycolic Acid Mesh Sheet (NeoveilTM)" on the thyroid cancer surgery.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Thoracic Duct Leak | — | UNRESOLVED | — |
| Thyroid Cancer | Malignant Thyroid Gland Neoplasm | CURATED_EXACT | 0.92 |
| Thyroid Gland Carcinoma | Thyroid Gland Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Neoveil (Polyglycolic Acid Mesh) | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- NO_INTERVENTION
- label
- Control
- description
- No use of Neoveil in the neck node dissection area
- type
- EXPERIMENTAL
- label
- Neoveil
- description
- Use of Neoveil in the neck node dissection area
- interventionNames
- Device: Neoveil (Polyglycolic Acid Mesh)
Primary outcomes (1)
- measure
- Change of triglyceride(TG) level in drained fluid
- timeFrame
- Change from drain TG level from postoperative 1st day to postoperative 2nd day
- description
- Triglyceride level in the drained fluid, check time 9:00AM, unit : mg/dL
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * Patients who are between 20 and 70 years of age * Patients who agreed to the study * Patients undergoing thyroidectomy and cervical node dissection for thyroid cancer * Patients without perithyroidal organ infiltration or distant metastasis * Before the operation, bilateral vocal cord movement was normal * Patients without significant abnormal findings in laboratory tests before surgery Exclusion Criteria: * Patients judged to be inadequate by the person in charge of clinical trial * Aspirin, anti-platelet medication within 7 days of admission * Uncontrolled hypertension, diabetes, chronic renal failure, coagulation disorders * Cardiovascular disease (angina, heart failure, myocardial infarction, history of coronary artery disease, stroke, transient ischemic attack) * Drug abuse and alcohol abuse * History of esophagus and airway diseases * Patients who participated in other clinical trials within 30 days * Patients who had previous history of neck irradiation or neck surgery * Patients with a history of allergy to drugs * For women, pregnant and lactating patients
References
Publications (3)
- RESULTJang JY, Shin YC, Han Y, Park JS, Han HS, Hwang HK, Yoon DS, Kim JK, Yoon YS, Hwang DW, Kang CM, Lee WJ, Heo JS, Kang MJ, Chang YR, Chang J, Jung W, Kim SW. Effect of Polyglycolic Acid Mesh for Prevention of Pancreatic Fistula Following Distal Pancreatectomy: A Randomized Clinical Trial. JAMA Surg. 2017 Feb 1;152(2):150-155. doi: 10.1001/jamasurg.2016.3644. PMID 27784046
- RESULTKuwata T, Shinohara S, Takenaka M, Oka S, Chikaishi Y, Hirai A, Kuroda K, So T, Tanaka F. The impact of covering the bulla with an absorbable polyglycolic acid (PGA) sheet during pneumothorax surgery. Gen Thorac Cardiovasc Surg. 2016 Sep;64(9):558-60. doi: 10.1007/s11748-015-0545-8. Epub 2015 Apr 10. PMID 25860987
- RESULTKobayashi S, Takeda Y, Nakahira S, Tsujie M, Shimizu J, Miyamoto A, Eguchi H, Nagano H, Doki Y, Mori M. Fibrin Sealant with Polyglycolic Acid Felt vs Fibrinogen-Based Collagen Fleece at the Liver Cut Surface for Prevention of Postoperative Bile Leakage and Hemorrhage: A Prospective, Randomized, Controlled Study. J Am Coll Surg. 2016 Jan;222(1):59-64. doi: 10.1016/j.jamcollsurg.2015.10.006. Epub 2015 Oct 23. PMID 26597705