Clinical trial · Interventional
LLETZ Under General Versus Local Anesthesia
Large Loop Excision of the Transformatione Zone Under General Versus Local Anesthesia: a Randomized Trial.
NCT03494686CI-TRIAL-00044183completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The investigators conduct a prospective, randomized trial to assess the benefits of performing large loop excision of the transformatione zone (LLETZ) under local anesthesia and compare it to LLETZ under general anesthesia. The primary endpoint of this study is women´s satisfaction.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Uterine Cervical Dysplasia | Cervical Intraepithelial Neoplasia | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| LLETZ under general anaesthesia | Procedure | — | UNRESOLVED |
| LLETZ under local anaesthesia | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- LLETZ under local anaesthesia
- description
- The LLETZ procedure will be performed under local anaesthesia
- interventionNames
- Procedure: LLETZ under local anaesthesia
- type
- ACTIVE_COMPARATOR
- label
- LLETZ under general anaesthesia
- description
- The LLETZ procedure will be performed under general anaesthesia
- interventionNames
- Procedure: LLETZ under general anaesthesia
Primary outcomes (1)
- measure
- Womens satisfaction
- timeFrame
- 2 hours
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * colposcopy Prior to conization * informed consent * histologically proven high grade cervical dysplasia * Transformation zone typ 1 or 2 Exclusion Criteria: * significant language barrier * a personal history of conization * pregnancy * the use of blood thinner * unwillingness to participate * oncological disease * inpatient treatment * women who are not fasting * risk of aspiration * columnar-squamous epithelium border not fully visible
References
Publications (1)
- DERIVEDRezniczek GA, Hecken JM, Rehman S, Dogan A, Tempfer CB, Hilal Z. Syringe or mask? Loop electrosurgical excision procedure under local or general anesthesia: a randomized trial. Am J Obstet Gynecol. 2020 Dec;223(6):888.e1-888.e9. doi: 10.1016/j.ajog.2020.06.041. Epub 2020 Jul 24. PMID 32585223