Bortezomib/Dexamethasone Therapy in Patients With Relapsed and/or Refractory Cutaneous T-cell Lymphoma

Inclusion Criteria:

* Histologically diagnosed subcutaneous skin T-cell lymphoma based on the WHO(World Health Organization)-EORTC classification (mycosis fungoides, Sezary syndrome,primary cutaneous anaplastic large cell lymphoma,lymphomatoid papulosis,primary cutaneous peripheral T-cell lymphoma, unspecified)
* Male and female patients aged 19-80
* ECOG(Eastern Cooperative Oncology Group performance) 0\~2
* Presence of measurable lesion according to ISCL(International Society for Cutaneous Lymphomas)-USCLC(United States Cutaneous Lymphoma Consortium)-EORTC(European Organization of Research and Treatment of Cancer) recommendation
* If one or more of the previous treatments fails or has recurred / progressed
* Proper function status of bone marrow, kidney, liver
* All toxic effects due to previous treatment have been resolved to CTCAE 4.03 version 1 or lower
* For pregnant women, the result of pregnancy test is negative. (The pregnant female patient should have effective contraception during the treatment period and for one month thereafter) (ie, hormonal contraceptive device, intrauterine device, diaphragm with spermicide, condom with spermicide, or abstinence) Men should use effective contraception during the treatment period and for three months thereafter.)
* Patients who are expected to follow and comply with the clinical trial protocol at the discretion of the tester
* Patients who voluntarily agreed to participate in this trial and signed a consent form
* Patients who agreed to donate a sample of peripheral lesions (10 unstained slides) and 3 ml of peripheral blood after baseline and cycle 8

Exclusion Criteria:

* Patients undergoing chemotherapy at the time of clinical trials
* Patients who are undergoing radiotherapy at the time of their participation in the trial or who received radiotherapy within the first 6 months of the trial. However, patients who have additional lesions elsewhere in the main lesion may be eligible for clinical trials if they have completed local radiotherapy as a palliative treatment prior to the administration of the drug, and recovered from the resulting toxicity.
* Patients with symptomatic or uncontrolled angina and congestive heart failure, arrhythmia requiring drug therapy, significant risk of clinically significant myocardial infarction within 6 months prior to participation in this trial
* Patients with stable left ventricular ejection fraction less than the normal lower limit of each organ.
* Adverse Reactions Common Terminology Criteria 4.03 In case of infection in excess of grade 2 according to the standards. Hepatitis B is allowed if there is no active replication (HBV DNA\> 20,000 iU / mL associated with ALT(alanine aminotransferase) exceeding twice the normal upper limit).
* If there is active infection, including severe concomitant disease and / or active hepatitis C and human immunodeficiency virus infection
* Patients who received chemotherapy, surgical treatment (permissive for mild surgical treatment) within 4 weeks of the administration of this drug
* History of allogeneic transplantation (including hematopoietic stem cell transplantation)
* Patients with a malignant tumor other than the target disease. However, the following cases are allowed.If you have not received treatment for the tumor for at least 5 years or have no disease,Complete resection of basal cell carcinoma / squamous cell carcinoma or at least 1 year after successful treatment of cervical intraepithelial cancer
* Adverse reactions within 30 days prior to the start of screening Common Grade Criteria 4.03 Severe gastrointestinal bleeding in excess of grade 2
* The occurrence of thrombosis or embolism within 6 months before screening
* Patients with central nervous system involvement.
* Pregnant, lactating, or reproductive women who are not willing to use appropriate contraception during the trial
* Unstable conditions that may impair patient safety and compliance with the test
* Patients with seizure disorders requiring medication
* If you have substance abuse, medical, mental or social illnesses that may interfere with the patient's participation in the clinical trial or the evaluation of clinical trial results
* Patients with a history of hypersensitivity to Drug or Drug component (bortezomib, boron, mannitol, dexamethasone)
* Patients with Acute Diffuse Invasive Pulmonary Disease and Cardiovascular Disease