Clinical trial · Observational
Research for Associated Genes for Gastric Cancer in Family Member With Affected First-Degree Relatives
Research for Associated Genes for Developing Gastric Cancer in Family Member With First-Degree Relatives of Gastric Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Familial gastric cancer accounts for 10% of all cases, but predisposing genetic variations is unknown except for CDH1 mutation. Because Germline mutation is believed to be a key aspect of cancer predisposition, we plan to recruit persons with 2 or more affected family members in three-generation pedigree. The investigators will perform a whole-exome sequencing using DNA from blood samples of families including gastric cancer patients and non-gastric cancer patients
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gastric Cancer | Malignant Gastric Neoplasm | CURATED_BROADER | 0.80 |
| Genetic Predisposition | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Positive result from pathological test | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Gastric cancer
- description
- Pathologically proven diseases after upper gastroendoscopy and biopsy. Previous pathological reports and endoscopic image can be used.
- interventionNames
- Diagnostic Test: Positive result from pathological test
- label
- non-gastric cnacer
- description
- Rull out gastric cancer by upper gastroendoscopy. The results 3 moths before enrollment is available.
Primary outcomes (1)
- measure
- Genes with logarithm of odds (LOD)>2 in linkage analysis
- timeFrame
- 0 day (baseline)
- description
- Based on LOD at baseline, candidate genes will be selected.
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria : * Gastric cancer patients and their first-degree relatives * Members in family with two or more gastric cancer patients within three- generation pedigree Exclusion Criteria : * Those who reject the enrollment
References
Publications (0)
Data not yet available