Therapeutic Virtual Reality : Impact on the Management of Pain and Anxiety Related to Hematology Care (REVEH)

Inclusion Criteria:

1. Patient with malignant haematological pathology
2. Patient who must have an osteo-medullary biopsy for diagnostic purposes
3. Age ≥ 18 years
4. Performance Status \< 3
5. Patient with no pelvic bone pain before inclusion
6. Patient with normal coagulation balance (TP, Activated Partial Thromboplastin Time, fibrin) and platelet count\> 50 G / L
7. Patient affiliated to the social security scheme
8. Patient giving written consent before any specific procedure related to the study

Exclusion Criteria:

1. Patient regularly taking antalgic treatments from stage 2 or 3
2. Patient with congenital coagulation disorder or acquired or taking anticoagulant therapy such as: fluindione, acenocoumarol, warfarin, dabigatran, apixaban or rivaroxaban
3. Contraindication to a gas mixture composed of 50% Nitrous Oxide, 50% Oxygen administration: true allergy, severe respiratory failure requiring continuous oxygen therapy, emphysema, pneumothorax, history of air embolism or diving accident, epilepsy or uncontrolled neurological disorder, unsubstituted vitamin deficiency B12 and folic acid, abdominal gas distension
4. Any contraindication to the use of the headset: pacemaker or other implanted medical device
5. Pregnancy or breastfeeding
6. Persons deprived of liberty, under guardianship or under guardianship
7. Dementia, mental impairment or psychiatric condition that may compromise patient informed consent and / or protocol compliance and follow-up of the trial
8. Patient unable to undergo protocol monitoring for psychological, social, family or geographical reasons