Clinical trial · Interventional
Effects of Nonintubated Thoracoscopic Lobectomy on Lung Protection
Effects of Nonintubated Thoracoscopic Lobectomy on Lung Protection: A Randomized Controlled Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
A novel nonintubated thoracoscopic technique is promising to enhance recovery after thoracic surgery. However, the effects of nonintubated technique on specific organ protection in not clear yet. In this randomized trial, the effect of nonintubated technique on lung function protection will be evaluated via PaO2/FiO2 ratio, oxidative stress and inflammatory cytokines serially in lung cancer patients undergoing thoracoscopic lobectomy.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Function Decreased | — | UNRESOLVED | — |
| Non-small Cell Lung Cancer | Lung Non-Small Cell Carcinoma | ALIAS | 0.90 |
| Tracheal Intubation Morbidity | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Intubated thoracoscopic lobectomy | Procedure | — | UNRESOLVED |
| Nonintubated thoracoscopic lobectomy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Nonintubated thoracoscopic lobectomy
- description
- Lung cancer patients undergoing thoracoscopic lobectomy without tracheal intubation
- interventionNames
- Procedure: Nonintubated thoracoscopic lobectomy
- type
- ACTIVE_COMPARATOR
- label
- Intubated thoracoscopic lobectomy
- description
- Lung cancer patients undergoing thoracoscopic lobectomy with tracheal intubation and one-lung ventilation
- interventionNames
- Procedure: Intubated thoracoscopic lobectomy
Primary outcomes (1)
- measure
- Lung function assessment
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 99 Years
Show eligibility criteria text
Inclusion criteria * adults (\> 20 year-old), lung cancer patients undergoing thoracoscopic lobectomy Exclusion criteria * obesity (BMI \> 26 kg/m2) * previous ipsilateral thoracic surgery * severe ventilatory insufficiency (oxygen/BiPAP user) * poor cardiopulmonary function (preop forced expiratory volume at one second (FEV1) \<60%, preop left ventricular ejection fraction \< 50%) * autoimmune disease requiring chronic steroids * patients with difficult airway management, pregnant women
References
Publications (0)
Data not yet available