Clinical trial · Interventional
Maintain Respiratory Muscle Function and Reduce Pneumonia Risk in Cancer Patients
Resistance Training and 1,25 (OH)2D3 Administration to Maintain Respiratory Muscle Function and Reduce Pneumonia Risk in Cancer Patients
NCT03469271CI-TRIAL-00069922completedPhase 4Results postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This research is intended to begin to explore the impact of inspiratory muscle resistance exercise and/or 1,25(OH)2D3 for improving respiratory muscle strength in cancer patients (subjects).
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (5)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 1,25 (OH)2 D3 | Drug | — | UNRESOLVED |
| Inspiratory isometric resistance training | Other | — | UNRESOLVED |
| Oral Placebo | Drug | — | UNRESOLVED |
| Sham Inspiratory Isometric Resistance Training | Other | — | UNRESOLVED |
| Threshold Inspiratory Muscle Trainer (IMT) | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- OTHER
- label
- Training and Placebo
- description
- Inspiratory isometric resistance training with the Threshold Inspiratory Muscle Trainer (IMT) plus oral placebo for eight weeks
- interventionNames
- Other: Inspiratory isometric resistance training
- Drug: Oral Placebo
- Device: Threshold Inspiratory Muscle Trainer (IMT)
- type
- OTHER
- label
- Sham Training and Vitamin D3 Metabolite
- description
- Sham inspiratory isometric resistance training with the Threshold Inspiratory Muscle Trainer (IMT) plus 1,25 (OH)2 D3 orally for eight weeks
- interventionNames
- Drug: 1,25 (OH)2 D3
- Other: Sham Inspiratory Isometric Resistance Training
- Device: Threshold Inspiratory Muscle Trainer (IMT)
- type
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosis of cancer * Renal and hepatic function (creatinine \</= 2 x the institutional upper limit of normal; bilirubin \</= 2 x the institutional upper limit of normal) * No contraindication to receive either of the planned interventions of inspiratory resistance training or 1,25(OH)2D3 in the opinion of the healthcare provider * No difficulties with swallowing oral medications in the opinion of the enrolling physician Exclusion Criteria: * Patient is taking calcium or Vitamin D supplements and is unwilling to stop for 8 weeks * Severe chronic obstructive pulmonary disease (oxygen dependent or patient self-reports unable to walk one block without difficulty) * Calcium or phosphorus level above the institutional upper limit of normal
References
Publications (0)
Data not yet available
No reference posted for this study.