Study on Decitabine Plus Carboplatin Versus Physician's Choice Chemotherapy in Recurrent, Platinum-resistant Ovarian Cancer.

Inclusion Criteria:

* Cytologic / histologic diagnosis of stage 1°C-4° epithelial , fallopian tube and primary peritoneal cancer (carcinosarcomas are included)
* Patient who received 1-2 prior lines of treatments
* Patient relapsed within 6 months after platinum containing regimen
* Disease measurable or evaluable by RECIST version 1.1 or Ca 125 GCIG criteria (Gynaecologic Cancer Intergroup).
* No residual peripheral neurotoxicity \> Grade 1 from previous chemotherapy treatment
* Performance Status (PS) 0-1
* Age 18 years.
* Life expectancy of at least 3 months
* Written informed consent prior to performance of study specific procedures or assessments
* Ability and willingness to comply with treatment and follow up assessments and procedures
* Adequate organ functions:

  1. Hematopoietic: Leukocytes \> 2,500/mm3; Absolute neutrophil count \>1,500/mm3; Platelets count \>100,000/mm3; Hemoglobin \>9 g/dL
  2. Hepatic: AST (aspartate transaminase ) and ALT (alanine transaminase) \<3 times upper limit of normal (ULN)\*; Alkaline phosphatase \<3 times ULN\*; Bilirubin \<1.5 times ULN

     \*: \<5 times ULN if liver metastases are present
  3. Renal: Creatinine clearance \>45 mL/min
* No other invasive malignancy within the past 3 years except non-melanoma skin cancer and in situ cervical cancer
* Absence of any psychological, familial, sociological or geographical conditions potentially hampering compliance with the study protocol and follow-up schedule.

Exclusion Criteria:

* Pregnant (potentially fertile patients must use contraceptive measures to avoid pregnancy during and for at least 3 months after study participation and must have a negative serum pregnancy test at baseline).
* Patients should not be breast-feeding during treatment and for 2 months following the end of treatment.
* Serious heart disease, including heart failure, atrio-ventricular block of any degree, serious arrhythmia or history of any one or more of the following cardiovascular conditions within the past 6 months: cardiac angioplasty or stenting, myocardial infarction, unstable angina, symptomatic peripheral vascular disease, coronary artery by-pass graft surgery, class II, III or IV congestive heart failure as defined by the New York Heart Association (NYHA)
* Active infection requiring antibiotics.
* History of cerebrovascular accident, pulmonary embolism or untreated deep venous thrombosis (DVT) within the past 6 months
* History of human immunodeficiency virus (HIV) infection or chronic hepatitis B or C.
* Patients who had prior chemotherapy, targeted small molecule therapy, or radiation therapy within 4 weeks prior to study Day 1 or who has not recovered (i.e., ≤ Grade 1 or at baseline) from adverse events due to a previously administered agent. Note: Subjects with \< Grade 2 neuropathy or ≤ Grade 2 alopecia are an exception to this criterion and may qualify for the study.
* Patients with evidence of interstitial lung disease.
* Major surgical procedure, open biopsy, or significant traumatic injury within 3 weeks prior to beginning therapy, or anticipation of the need for a major surgical procedure during the course of the study; minor surgical procedures such as fine needle aspiration or core biopsy within 1 week prior to beginning therapy are also excluded.
* Known hypersensitivity to the study drugs or to drugs with similar chemical structures.
* Concurrent treatment with other experimental drugs.
* Participation in another clinical trial with any investigational drug within 30 days prior to study screening.