Clinical trial · Interventional
IVM Versus Standard IVF in Infertile Patients Diagnosed With PCOS
In Vitro Maturation Versus Standard in Vitro Fertilization in Infertile Patients Diagnosed With Polycystic Ovaries Syndrome: a Study Protocol for a Single-center Prospective, Randomized Controlled Clinical Trial
NCT03463772CI-TRIAL-00041335unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
A single center, prospective, open-label, non-inferiority randomized controlled clinical trials (1:1 treatment ratio) regarding pregnancy outcomes between IVM and standard IVF among infertility couples with PCOS in China.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| PCOS | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| In vitro maturation | Drug | — | UNRESOLVED |
| standard IVF | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- standard IVF
- description
- On the Day2/3 of the menstrual cycle, qualified participants will be randomized into either of two groups. Participants in group A will receive standard IVF procedure. Other standard assisted reproductive treatments are similar and parallel between two groups.
- interventionNames
- Procedure: standard IVF
- type
- ACTIVE_COMPARATOR
- label
- In vitro maturation
- description
- On the Day2/3 of the menstrual cycle, qualified participants will be randomized into either of two groups. Participants in group B will receive IVM procedure.Other standard assisted reproductive treatments are similar and parallel between two groups.
- interventionNames
- Drug: In vitro maturation
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 20 Years
- Maximum age
- 38 Years
Show eligibility criteria text
Inclusion Criteria: 1. Infertile couples scheduled for their first IVF cycle. 2. Women diagonosed with polycystic ovarian syndrome. 3. Voluntary participation and informed consent obtained. Exclusion Criteria: 1. Couple with contraindication for IVF or ICSI. 2. Couples receiving donor sperm or donor eggs. 3. Couples with indications or have plan to receive PGD and PGS. 4. Sperm analysis diagnosed as azoospermia; 5. Either male partner or female partner with an abnormal chromosome karyotype (chromosome polymorphisms was not included). 6. Women who have undergone unilateral ovariectomy.
References
Publications (3)
- DERIVEDGuo W, Yang Y, Qin M, Kong S, Wang L, Zheng X, Yang R, Yang S, Zhen X, Zhu X, Li R, Yan L, Qiao J, Yan Z. Epigenetic safety of in vitro maturation in PCOS: genome-wide DNA methylation profiling of cord blood from a randomized controlled trial. J Ovarian Res. 2026 Jun 27. doi: 10.1186/s13048-026-02179-7. Online ahead of print. PMID 42365361
- DERIVEDZheng X, Guo W, Zeng L, Zheng D, Yang S, Xu Y, Wang L, Wang R, Mol BW, Li R, Qiao J. In vitro maturation without gonadotropins versus in vitro fertilization with hyperstimulation in women with polycystic ovary syndrome: a non-inferiority randomized controlled trial. Hum Reprod. 2022 Jan 28;37(2):242-253. doi: 10.1093/humrep/deab243. PMID 34849920
- DERIVEDZheng X, Guo W, Zeng L, Zheng D, Yang S, Wang L, Wang R, Mol BW, Li R, Qiao J. Live birth after in vitro maturation versus standard in vitro fertilisation for women with polycystic ovary syndrome: protocol for a non-inferiority randomised clinical trial. BMJ Open. 2020 Apr 14;10(4):e035334. doi: 10.1136/bmjopen-2019-035334. PMID 32295778