Clinical trial · Interventional
The Effects of Optimizing Post-operative Pain Management With Multi Modal Analgesia on Immune Suppression and Oncologic Outcome in Patients Undergoing Laparoscopic Colorectal Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): The results of the primary endpoints of this study are expected to be difficult to identify, thus canceling the study to readjust the study plan.
Summary
Brief summary (as posted)
Traditionally, pain control methods based on narcotic analgesics have been used to control severe pain after surgery, but this has resulted in side effects such as vomiting, constipation, dizziness, mental confusion due to drugs, and respiratory depression. This slowed the recovery of the patient after surgery and increased the duration of hospitalization, which had a negative impact on the patient 's prognosis. In addition, research has been conducted on the use of various painkillers in a variety of ways over the past decade to reduce the dose of narcotic analgesics and to increase the effectiveness of pain control, since studies of anesthetics and narcotic analgesics have shown immunosuppressive effects. This study investigate the effect of multimodal analgesics for postoperative pain control on immune function amd prognosis in patients undergoing laparoscopic colorectal cancer resection.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Laparoscopic Colorectal Resection Due to Cancer | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| IV ketamine/lidocaine/IV PCA apply | Drug | — | UNRESOLVED |
| IV PCA only apply | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- IV ketamine/lidocaine/IV PCA (MA) group
- description
- In addition to basic anesthetic methods, multimodal analgesia with IV ketamine, lidocaine and IV PCA apply
- interventionNames
- Drug: IV ketamine/lidocaine/IV PCA apply
- type
- ACTIVE_COMPARATOR
- label
- IV PCA only (CA) group
- description
- In addition to basic anesthetic methods, only IC PCA apply for pain control
- interventionNames
- Drug: IV PCA only apply
Primary outcomes (1)
- measure
- natural killer cell cytotoxicity
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: 1. elective laparoscopic colorectal resection due to colorectal cancer 2. curative, resectable operation 3. ASA classification Ⅰ-Ⅲ Exclusion Criteria: 1. elective co-operation due to distance metastasis 2. preoperative chemo/radiation therapy 3. drug allergy to opioid, tramadol, local anesthetics 4. MAOi medication (within 14 days of surgery) 5. decreased hepatic/renal function 6. Patients who can not read the consent form or are not fluent in Korean (illiterate, foreigner 7. pregnant, lactating women 8. palliative surgery
References
Publications (0)
Data not yet available