Clinical trial · Interventional
Quad Resection (Hot Snare vs Cold Snare vs Hot EMR vs Cold EMR)
A Randomized Trial Comparing the Effectiveness of Polyp Resection Treatments (Hot Snare vs Cold Snare vs Hot EMR vs Cold EMR)
NCT03462706CI-TRIAL-00063955completedN/AResults postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The study will compare the use of cold snare, hot snare, cold EMR, and hot EMR for polyp resection. Although previous studies have compared two of the potential resection methods, no previous study has evaluated all four of the resection methods.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colon Adenoma | Colon Adenoma | ONTOLOGY_EXACT | 0.98 |
| Colon Cancer | Malignant Colon Neoplasm | CURATED_EXACT | 0.92 |
| Colon Polyp | — | UNRESOLVED | — |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Cold EMR | Procedure | — | UNRESOLVED |
| Cold Snare | Procedure | — | UNRESOLVED |
| Hot EMR | Procedure | — | UNRESOLVED |
| Hot Snare | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- EXPERIMENTAL
- label
- Cold Snare
- description
- Polyps sized 6mm to 15mm found during colonoscopy will be removed using cold snare techniques.
- interventionNames
- Procedure: Cold Snare
- type
- EXPERIMENTAL
- label
- Hot Snare
- description
- Polyps sized 6mm to 15mm found during colonoscopy will be removed using hot snare techniques.
- interventionNames
- Procedure: Hot Snare
- type
- EXPERIMENTAL
- label
- Cold EMR
- description
- Polyps sized 6mm to 15mm found during colonoscopy will be removed using cold EMR techniques.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 40 Years
Show eligibility criteria text
Inclusion Criteria: * Aged 40 years or older * Ability to provide informed consent Exclusion Criteria: * Subjects with a history of Inflammatory Bowel Disease * Lesions less than 6mm or greater than 15mm in largest dimension
References
Publications (1)
- DERIVEDRex DK, Anderson JC, Pohl H, Lahr RE, Judd S, Antaki F, Lilley K, Castelluccio PF, Vemulapalli KC. Cold versus hot snare resection with or without submucosal injection of 6- to 15-mm colorectal polyps: a randomized controlled trial. Gastrointest Endosc. 2022 Aug;96(2):330-338. doi: 10.1016/j.gie.2022.03.006. Epub 2022 Mar 12. PMID 35288147