Clinical trial · Interventional
Prospective Assessment of Radiation-induced Heart Injury in Left-sided Breast Cancer
Prospective Assessment of Radiation-induced Heart Injury in Left-sided Breast Cancer Treated With Breast Conserving Surgery Followed by Radiotherapy With Free-breathing or Deep Inspiration Breath-hold (DIBH) Technique
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study is to prospectively investigate the cardiac dose-sparing effect and clinical benefit of deep inspiration breath-hold (DIBH) technique. Patients with left-sided breast cancer treated with breast conserving surgery followed by radiotherapy is enrolled. Radiotherapy is delivered with either free-breathing or deep inspiration breath-hold (DIBH) technique. The cardiac dose parameters and cardiac toxicity are prospective evaluated, and the dose-effect relationship is analyzed.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Neoplasms | Breast Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Heart Injuries | — | UNRESOLVED | — |
| Radiation Toxicity | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| deep inspiratory breath-holding | Radiation | — | UNRESOLVED |
| free-breathing | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Free-breathing
- description
- standard treatment
- interventionNames
- Radiation: free-breathing
- type
- EXPERIMENTAL
- label
- Deep inspiratory breath-holding
- description
- new technique
- interventionNames
- Radiation: deep inspiratory breath-holding
Primary outcomes (1)
- measure
- Number of participants with treatment-related cardiac adverse events as assessed by CTCAE v4.0
- timeFrame
- up to 2 years
- description
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: 1. Left-sided breast cancer 2. Underwent breast conserving surgery 3. Planned for postoperative whole breast +- regional nodal radiotherapy 4. No basic heart disease Exclusion Criteria: 1. Abnormal cardiac baseline examination 2. History of chest radiation 3. Can not tolerate deep inspiratory breath-holding
References
Publications (0)
Data not yet available