Clinical trial · Interventional
Evaluating Race Specific AGE Accumulation As a Behavioral Biomarker Prostate Cancer Survivors
Evaluating Race Specific AGE Accumulation As a Behavioral Biomarker That Can Reflect Optimal Health in Prostate Cancer Survivors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): investigator decision
Summary
Brief summary (as posted)
The purpose of this study is to show that reduction in advanced glycation end-products (AGEs) is associated with the beneficial regulation of receptor for AGE (RAGE) mediated tumor response which may correlate with improved quality of life in PCa survivors. AGEs are produced by the body and are affected by lifestyle, weight and diet.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Prostate Cancer | Malignant Prostate Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Physical Activity | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Lifestyle Intervention
- description
- Patients assigned to the Physical Activity arm will undergo exercise testing protocol and have supervised physical activity interventions while on study. Patients will also complete questionnaires and have research blood drawn.
- interventionNames
- Behavioral: Physical Activity
- type
- NO_INTERVENTION
- label
- Usual care
- description
- Patients will complete questionnaires and have research blood drawn.
Primary outcomes (2)
- measure
- Compare RAGE response (measured in the blood) to changes in Quality of Life using the EORTC QLQ-30 questionnaire.
- timeFrame
- From baseline to up to 52 weeks
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 45 Years
Show eligibility criteria text
Inclusion Criteria: 1. Patient diagnosed with non-metastatic Stage I-III Prostate Cancer 2. Age 45 years and older 3. Within 12 months of first histologic prostate cancer diagnosis. 4. Completed planned chemotherapy and/or radiation therapy 4 weeks or more prior to study. 5. BMI \> 25 6. ECOG Performance Status 0 or 1. 7. Access to a telephone. 8. Able to read and understand written and spoken English. 9. Participants must be accessible for treatment and follow-up and must sign informed consent. 10. Subjects with known diabetes are permitted. However, they must be under active treatment for this condition. 11. Participants must past the cardiac rehabilitation center stress test. Exclusion Criteria: 1. Planned enrollment in other formalized physical activity or diet counseling program during the 12 weeks of study 2. Received chemotherapy or radiation therapy within 4 weeks of enrollment 3. Had previous weight loss surgery (e.g. gastric bypass, sleeve gastrectomy and biliary pancreatic diversion). 4. Previously participated in Cardiac-Rehab 5. Have constrained mobility secondary to problems with balance, bone and/or joint disease 6. Have unstable angina or cardiovascular disease that prohibits exercise.
References
Publications (0)
Data not yet available