Clinical trial · Interventional
Efficacy of Doxycycline in the Treatment of Early Stages of Mycosis Fungoides
Efficacy of Doxycycline in the Treatment of Early Stages of Mycosis Fungoides: A Randomized Controlled Trial
NCT03454945CI-TRIAL-00034526unknownPhase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Current study aims at assessing the efficacy of doxycycline as a potential treatment modality for early stages of MF.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lymphoma | Lymphoma | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Phototherapy | Device | — | UNRESOLVED |
| Vibramycin | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Doxycyline
- description
- Oral Vibramycin antibiotic100 mg capsule every 12 hours for 3 months
- interventionNames
- Drug: Vibramycin
- Device: Phototherapy
- type
- ACTIVE_COMPARATOR
- label
- Phototherapy
- description
- UVA+ psoralen 3 sessions per week for 3 months
- interventionNames
- Drug: Vibramycin
- Device: Phototherapy
Primary outcomes (1)
- measure
- Clinical assessment
- timeFrame
- 3 months
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adults (above 18) of either sex with established diagnosis of classic MF Exclusion Criteria: * Any variant of MF other than the classic variant. * Advanced stages of classic MF: Stage IIb, III or IV. * Pregnant and lactating females. * Patients with autoimmune diseases e.g. SLE * Patients with solid or hematological malignancies e.g. breast cancer, leukemia, etc. * Patients with any contraindications for doxycycline (eg: liver disease, kidney disease, photosensitivity, peptic ulcer or patients receiving systemic retinoids). * Patients with any contraindication to phototherapy (eg: any other skin cancers or photosensitivity); or to psoralen (eg: liver disease)
References
Publications (2)
- DERIVEDValipour A, Jager M, Wu P, Schmitt J, Bunch C, Weberschock T. Interventions for mycosis fungoides. Cochrane Database Syst Rev. 2020 Jul 7;7(7):CD008946. doi: 10.1002/14651858.CD008946.pub3. PMID 32632956
- DERIVEDEl Sayed H, Shalaby S, Abdel-Halim MRE, Aboelfadl DM, Samir N. Efficacy of doxycycline in the treatment of early stages of mycosis fungoides: a randomized controlled trial. J Dermatolog Treat. 2021 Jun;32(4):424-431. doi: 10.1080/09546634.2019.1667474. Epub 2019 Sep 20. PMID 31526286