Clinical trial · Interventional
Effect of Photodynamic Therapy on Gingival Crevicular Cytokines in Periodontitis Patients
NCT03453476CI-TRIAL-00031925completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Systemically healthy periodontitis patients were recruited in this single-blind, split-mouth, randomized controlled clinical trial. After SRP, PDT was applied at probing depth (PD) ≥ 4 mm at test quadrant. At baseline, 3rd month and 6th month, clinical parameters and cytokine pattern in gingival crevicular fluids (GCFs) were analysed.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Periodontal Attachment Loss | — | UNRESOLVED | — |
| Periodontal Pocket | — | UNRESOLVED | — |
| Periodontitis | — | UNRESOLVED | — |
| Periodontitis, Adult | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| SRP and Fotosan 630 | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- SRP and Fotosan 630
- description
- Scaling and root planing, photodynamic therapy using Fotosan 630
- interventionNames
- Device: SRP and Fotosan 630
- type
- NO_INTERVENTION
- label
- Control
- description
- Scaling and root planing only
Primary outcomes (9)
- measure
- Changes from baseline probing depth at 3rd month and 6th month
- timeFrame
- 3 months and 6 months
- description
- Clinical probing depth in mm
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 21 Years
Show eligibility criteria text
Inclusion Criteria: * Adults who were medically fit or have medical condition that did not alter the outcome of periodontal treatment. * Females who were not pregnant or nursing. * Controlled diabetes mellitus with HbA1c \< 7.5 mmol/L. * Not on any antibiotics or steroids 3 months prior to periodontal treatment. * Diagnosed to have either localized or generalized chronic or aggressive periodontitis (Armitage, 1999) with all 4 quadrants having at least 2 sites with probing depth ≥ 4 mm. * Consented to follow the non-surgical periodontal treatment (scaling and root planing) with PDT throughout the period of study, i.e. approximately 6 months. Exclusion Criteria: * Allergic to photosensitizer or dye * Pregnant lady and nursing mothers * Uncontrolled diabetes
References
Publications (0)
Data not yet available
No reference posted for this study.