Clinical trial · Observational
Study of First-line Treatment Patterns and Clinical Outcomes in Patients With Advanced Melanoma in the United Kingdom
Retrospective Chart Review Study of First-line Treatment Patterns and Clinical Outcomes in Patients With Advanced (Unresectable or Metastatic) Melanoma in the United Kingdom
NCT03448497CI-TRIAL-00039890completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to describe the first-line therapy landscape for patients with advanced melanoma and to describe clinical outcomes and healthcare resource utilization in a subset of treatment-naïve patients who initiated nivolumab + ipilimumab combination therapy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Melanoma | Melanoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Non-interventional | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Advanced Melanoma patients who intiated first-line therapy
- description
- patients who initiated any first-line therapy for advanced melanoma and had not previously received treatment for their advanced disease
- interventionNames
- Other: Non-interventional
Primary outcomes (1)
- measure
- Best Overall Response (BOR) rate
- timeFrame
- Up to 18 months
- description
- In a subset of patients treated with first-line nivolumab + ipilimumab combination therapy
Secondary outcomes (14)
- measure
- Distribution of patient demographic characteristics
- timeFrame
- At baseline
- description
- Including age, sex, ethnic group, height, weight, and BMI
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
For more information regarding Bristol-Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com Inclusion Criteria: * Patient has medical chart documentation of advanced (unresectable or metastatic) melanoma. * Patient initiated a first-line therapy for the treatment of advanced melanoma during the eligibility period (01 July 2016 to 01 July 2017; index event). * Patient did not receive systemic treatment for their advanced (unresectable or metastatic) melanoma prior to index event * Patient initiated first-line therapy at least six months before the date their chart abstraction initiated Exclusion Criteria: * Patient was enrolled in an investigational drug clinical trial or participating in medical research judged to directly affect how the patient was being monitored/treated while receiving first-line therapy * Patient had another active concurrent malignancy other than advanced melanoma, which required systemic treatment at the time of index event * Part or all of the patient's first-line treatment was received at a different site and the patient's medical chart pertaining to this care is not accessible * Patient medical chart is missing, empty, or not retrievable Other protocol defined inclusion/exclusion criteria could apply
References
Publications (0)
Data not yet available
No reference posted for this study.