Clinical trial · Interventional
The Therapeutic Time Window of Mannitol During Craniotomy for Optimal Brain Relaxation in Patients With Supratentorial Tumours
Brain Relaxation Facilitated by Mannitol in Craniotomy: Insight Into the Optimized Operation Window
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Although mannitol is used for brain relaxation during neurosurgery and in the treatment of raised intracranial pressure; there is not a consensus on its safe, effective dose and the duration of its administration. This study aimed to compare the effects of the mannitol in different use times, on the brain relaxation, electrolyte, lactate levels of the blood, peroperative fluid balance and the volume of the urine in supratentorial mass resection surgeries.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Supratentorial Tumors | Supratentorial Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Mannitol | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Mannitol A
- description
- in this group, Mannitol (1.0g/kg) is given just after the induction of general anesthesia
- interventionNames
- Drug: Mannitol
- type
- ACTIVE_COMPARATOR
- label
- Mannitol B
- description
- in this group, Mannitol (1.0g/kg) is given at the time of skin incision
- interventionNames
- Drug: Mannitol
Primary outcomes (1)
- measure
- brain relaxation score
- timeFrame
- just before dural opening
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 60 Years
Show eligibility criteria text
Inclusion Criteria: * Intracranial shift \>3mm * Scheduled for supratentorial mass resection under elective conditions Exclusion Criteria: * Decompensated heart failure * kidney insufficiency * Diabetes insipidus, * Electrolyte imbalance and * Who are unconscious
References
Publications (0)
Data not yet available