Clinical trial · Observational
Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patients
Cardiovascular Research Consortium - a Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patients
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The objective of CAREBANK study is to establish definitive relationships with human cardiac samples and clinical phenotypes in patients undergoing cardiac procedures. Specifically, the investigators aim at comparing atrial phenotypes from atrial fibrillation patients and controls. The work consists of three broad categories: A) role of atrial cardiomyopathy in atrial fibrillation; B) genetic defects predisposing to atrial fibrillation; and C) the role of inflammation in atrial fibrillation.
Conditions
Conditions (8)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Aortic Valve Disease | — | UNRESOLVED | — |
| Aortic Valve Stenosis | — | UNRESOLVED | — |
| Atrial Fibrillation | — | UNRESOLVED | — |
| Cardiac Arrythmias | — | UNRESOLVED | — |
| Cardiac Surgery | — | UNRESOLVED | — |
| Cardiac Tumor | Heart Neoplasm | ALIAS | 0.90 |
| Coronary Artery Disease | — | UNRESOLVED | — |
| Mitral Valve Disease | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Cardiac surgery | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (5)
- label
- Atrial fibrillation
- description
- Patients with atrial fibrillation
- interventionNames
- Procedure: Cardiac surgery
- label
- Coronary bypass
- description
- Patients undergoing coronary bypass
- interventionNames
- Procedure: Cardiac surgery
- label
- Aortic valve replacement
- description
- Patients undergoing aortic valve replacement
- interventionNames
- Procedure: Cardiac surgery
- label
- Mitral valve repair
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Any open-heart cardiac surgery * Written informed consent * All-comers design Exclusion Criteria: * No informed consent
References
Publications (4)
- DERIVEDViikinkoski E, Lehto J, Relander A, Jalkanen J, Gunn J, Vasankari T, Biancari F, Airaksinen JKE, Hollmen M, Kiviniemi TO. Prolonged Systemic Inflammatory Response Syndrome Predicts Atrial Fibrillation After Cardiac Surgery. Interdiscip Cardiovasc Thorac Surg. 2026 Mar 12;41(3):ivag081. doi: 10.1093/icvts/ivag081. PMID 41840772
- DERIVEDMaaniitty E, Sinisilta S, Jalkanen J, Vasankari T, Biancari F, Gunn J, Jalkanen S, Airaksinen KEJ, Hollmen M, Kiviniemi T. Distinct circulating cytokine levels in patients with angiography-proven coronary artery disease compared to disease-free controls. Int J Cardiol Cardiovasc Risk Prev. 2024 Jul 4;22:200307. doi: 10.1016/j.ijcrp.2024.200307. eCollection 2024 Sep. PMID 39091640
- DERIVEDMaaniitty E, Jalkanen J, Sinisilta S, Gunn J, Vasankari T, Biancari F, Jalkanen S, Airaksinen KEJ, Hollmen M, Kiviniemi T. Differential circulating cytokine profiles in acute coronary syndrome versus stable coronary artery disease. Sci Rep. 2024 Jul 27;14(1):17269. doi: 10.1038/s41598-024-68333-7. PMID 39068298
- DERIVEDViikinkoski E, Jalkanen J, Gunn J, Vasankari T, Lehto J, Valtonen M, Biancari F, Jalkanen S, Airaksinen KEJ, Hollmen M, Kiviniemi TO. Red blood cell transfusion induces abnormal HIF-1alpha response to cytokine storm after adult cardiac surgery. Sci Rep. 2021 Nov 15;11(1):22230. doi: 10.1038/s41598-021-01695-4. PMID 34782683