Clinical trial · Observational
Sweden Cancerome Analysis Network - Breast (SCAN-B) Coupled to Psychological Resilience
The Molecular Fingerprint of Psychological Resilience - Implications for Diagnostic and Therapeutic Strategies
NCT03430492CI-TRIAL-00087419active not recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 9, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260909-000002
Summary
Brief summary (as posted)
This study aims to define the association between psychological resilience and biomolecular signatures in cancer patients and to relate psychological resilience to prognosis, as this could potentially open up a novel avenue of therapeutic interventions, medical as well as psychosocial.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- The association between psychological resilience and biomolecular signatures in breast cancer patients
- timeFrame
- All patients enrolled 2019-12-31. Analysis 2020-2022
- description
- Measured by CD-RISC and bimolecular techniques.
Secondary outcomes (6)
- measure
- The association between psychological resilience and quality of life at baseline in breast cancer patients
- timeFrame
- All patients enrolled 2019-12-31. Analysis 2020-2022
- description
- Measured by CD-RISC and SF-36
- measure
- The association between psychological resilience and quality of life one year after diagnosis in breast cancer patients
- timeFrame
- Patients followed up one year from diagnosis. All patients enrolled 2019-12-31. Analysis 2020-2022
- description
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Newly diagnosed patients with primary breast cancer * Patients consented to be included in the SCAN-B study at (Blekinge County Hospital, Central Hospital Växjö and Hallands Hospital Halmstad HBG?? * Oral and written consent for the SCAN-B Resilience study * Age ≥ 18 years * Patients that do understand the Swedish language (written and spoken) Exclusion Criteria: * No diagnosis of breast cancer * Not consented to be included in the SCAN-B study * Do not understand the Swedish language
References
Publications (6)
- BACKGROUNDSaal LH, Vallon-Christersson J, Hakkinen J, Hegardt C, Grabau D, Winter C, Brueffer C, Tang MH, Reutersward C, Schulz R, Karlsson A, Ehinger A, Malina J, Manjer J, Malmberg M, Larsson C, Ryden L, Loman N, Borg A. The Sweden Cancerome Analysis Network - Breast (SCAN-B) Initiative: a large-scale multicenter infrastructure towards implementation of breast cancer genomic analyses in the clinical routine. Genome Med. 2015 Feb 2;7(1):20. doi: 10.1186/s13073-015-0131-9. eCollection 2015. PMID 25722745
- BACKGROUNDAxelsson U, Ryden L, Johnsson P, Eden P, Mansson J, Hallberg IR, Borrebaeck CAK. A multicenter study investigating the molecular fingerprint of psychological resilience in breast cancer patients: study protocol of the SCAN-B resilience study. BMC Cancer. 2018 Aug 6;18(1):789. doi: 10.1186/s12885-018-4669-y. PMID 30081937
- RESULTRichter C, Dethlefsen O, Axelsson U, Lundberg K, Ryden L, Johnsson P, Ringdahl U, Hallberg IR, Borrebaeck CAK. Multilayered Epigenetic Analysis Identifies a Molecular Portrait for Psychological Resilience in Patients With Breast Cancer. Biol Psychiatry Glob Open Sci. 2025 Jun 3;5(5):100545. doi: 10.1016/j.bpsgos.2025.100545. eCollection 2025 Sep. PMID 40697488
- RESULTMohlin A, Bendahl PO, Hegardt C, Richter C, Hallberg IR, Ryden L. Psychological Resilience and Health-Related Quality of Life in 418 Swedish Women with Primary Breast Cancer: Results from a Prospective Longitudinal Study. Cancers (Basel). 2021 May 6;13(9):2233. doi: 10.3390/cancers13092233. PMID 34066499
- RESULTMohlin A, Axelsson U, Bendahl PO, Borrebaeck C, Hegardt C, Johnsson P, Rahm Hallberg I, Ryden L. Psychological Resilience and Health-Related Quality of Life in Swedish Women with Newly Diagnosed Breast Cancer. Cancer Manag Res. 2020 Nov 24;12:12041-12051. doi: 10.2147/CMAR.S268774. eCollection 2020. PMID 33269004
- RESULTVelickovic K, Borrebaeck CAK, Bendahl PO, Hegardt C, Johnsson P, Richter C, Ryden L, Hallberg IR. One-year recovery from breast cancer: Importance of tumor and treatment-related factors, resilience, and sociodemographic factors for health-related quality of life. Front Oncol. 2022 Aug 16;12:891850. doi: 10.3389/fonc.2022.891850. eCollection 2022.