Clinical trial · Interventional
Continuous Positive Airway Pressure Device or Deep Inspiration Breath Hold in Reducing Tumor Motion in Patients Undergoing Stereotactic Body Radiation Therapy for Lung Cancer
Measuring the Effectiveness of a Continuous Positive Airway Pressure (CPAP) Device to Reduce Tumor Motion and Increase Lung Volume Expansion in Patients Undergoing Stereotactic Body Radiotherapy (SBRT) for Tumors That Move With Respiration
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This pilot phase I/II trial studies how well a continuous positive airway pressure device or deep inspiration breath hold works in reducing tumor movement in patients undergoing stereotactic body radiation therapy (SBRT) for lung cancer. The continuous positive airway pressure device works by blowing air into the lungs while patients wear a face mask or nozzle to help expand their airways and lungs. Deep inspiration breath hold is a standard technique that uses active breath-holding to restrict movement of the body. Using a continuous positive airway pressure device may work better than deep inspiration breath hold in lowering the amount of tumor movement during stereotactic radiation body therapy.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Carcinoma | Lung Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Malignant Respiratory Tract Neoplasm | Malignant Respiratory System Neoplasm | ALIAS | 0.90 |
| Metastatic Malignant Neoplasm in the Lung | Lung Neoplasm | PROBABILISTIC | 0.70 |
Interventions
Interventions (6)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Biphasic Positive Airway Pressure | Device | — | UNRESOLVED |
| Computed Tomography | Procedure | — | UNRESOLVED |
| Continuous Positive Airway Pressure | Procedure | — | UNRESOLVED |
| Deep Inspiration Breath Hold | Procedure | — | UNRESOLVED |
| Radiation Therapy Treatment Planning and Simulation | Radiation | — | UNRESOLVED |
| Stereotactic Body Radiation Therapy | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Treatment (CT simulation, CPAP, DIBH, SBRT, BiPAP)
- description
- Patients undergo free-breathing, DIBH, and CPAP CT simulation scans. If patient has difficulty exhaling on CPAP, then patient undergo BiPAP CT simulation. The attending physician then compares all 3 simulation treatment plans (free-breathing, DIBH, and CPAP/BiPAP) and determines which method to use during SBRT. If CPAP/BiPAP is chosen as preferred method, patients wear CPAP/BiPAP over 1 hour prior to SBRT, then again during SBRT over 30-60 minutes. All other patients complete free-breathing or DIBH during SBRT over 30-60 minutes.
- interventionNames
- Device: Biphasic Positive Airway Pressure
- Procedure: Computed Tomography
- Procedure: Continuous Positive Airway Pressure
- Procedure: Deep Inspiration Breath Hold
- Radiation: Radiation Therapy Treatment Planning and Simulation
- Radiation: Stereotactic Body Radiation Therapy
Primary outcomes (1)
- measure
- Estimation of decrease in tumor motion
- timeFrame
- Up to 10 days
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * The patient will receive stereotactic body radiotherapy in the Thoracic Radiation Oncolcogy Service at MD Anderson. Exclusion Criteria: * The patient has a contra-indication for using a CPAP device. * The patient has not signed a study-specific informed consent for this study. * The patient is uncooperative. * The patient has reduced consciousness. * The patient has sustained trauma or burns to the face. * The patient has undergone any facial, esophageal, gastric or sinus surgery within the last 3 months. * The patient has idiopathic pulmonary fibrosis (IPF) as documented in their medical history. * Adults who are unable to consent, individuals who are not yet adults, pregnant women and prisoners will be excluded from this study.
References
Publications (0)
Data not yet available