Clinical trial · Interventional
Action of Synbiotics on Irradiated GI Mucosa in Rectal Cancer Treatment
Randomized Clinical Trial of Effects of Synbiotics on Intestinal Microbiota in Patients Undergoing Short-course Preoperative Radiotherapy During Treatment of Rectal Cancer
NCT03420443CI-TRIAL-00031537FIPIREXcompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of this study is to investigate how bacteria and fibre interact with the epithelial cells of the gastrointestinal mucosa to reduce inflammation and to diminish tissue damage caused by radiation therapy to patients diagnosed with rectal cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Rectal Cancer | Malignant Rectal Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| No oral supplementation | Dietary Supplement | — | UNRESOLVED |
| Oat bran | Dietary Supplement | — | UNRESOLVED |
| Oat bran and blueberry husks | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- Oat bran
- description
- 45 g oat bran
- interventionNames
- Dietary Supplement: Oat bran
- type
- EXPERIMENTAL
- label
- Oat bran and blueberry husks
- description
- 13 g freeze dried blueberry husks and 22 g oat bran + probiotic bacteria.
- interventionNames
- Dietary Supplement: Oat bran and blueberry husks
- type
- OTHER
- label
- No oral supplementation
- description
- No oral supplementation.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Rectal cancer/Adenocarcinoma recti * Informed Consent explained orally and written, understood, agreed and signed Exclusion Criteria: * Diabetes Mellitus * Inflammatory bowel disease * Previous radiation to pelvis area * Ongoing steroid or immunosuppressive therapy * Ongoing antibiotics therapy
References
Publications (0)
Data not yet available
No reference posted for this study.