Expanded Access to Provide GL-ONC1 for the Treatment of Advanced Cancers With No Standard of Care

Inclusion Criteria:

* Diagnosis of advanced cancers with no standard of care option for treatment.
* Willing and able to provide written, signed informed consent.
* Use of adequate contraception.
* Negative pregnancy test.

Exclusion Criteria:

* Have not recovered from severe adverse events from prior therapy.
* Major surgery occurred within 28 days prior to treatment.
* Known immune system disorders such as HIV, or active hepatitis B or C infection.
* Clinically significant cardiac disease (New York Heart Association Class III or IV).
* Have received prior therapy with an oncolytic virus of any type.
* Be receiving antiviral agent active against vaccinia virus (e.g., cidofovir, vaccinia immunoglobulin, imatinib, ST-246).
* Have known allergy to ovalbumin or other egg products.
* Have clinically significant dermatological disorders (e.g., eczema, psoriasis, or any unhealed skin wounds or ulcers) as assessed by the treating physician.