Clinical trial · Interventional
The Accuracy of Modified TTMB in the Spatial Distribution of Prostate Cancer
The Study on the Spatial Distribution of Prostate Cancer by Modified Trans-perineal Template-guided Mapping Biopsy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Investigators plan to use modified TTMB technology to puncture prostate of participants suspected prostate cancer, especially those with the first negative biopsy , but having a rising PSA.Then, Investigators will simulate the spatial distribution of prostate cancer in patients with positive biopsy before radical prostatectomy by way of the TPS software system . And after the radical prostatectomy ,Investigators will simulate the spatial distribution with the help of large tissue slice technique to compare with preoperative simulation ,which to verify the two simulations are consistent.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Prostate Cancer | Malignant Prostate Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| trans-perineal template-guided mapping biopsy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- TTMB for patients
- description
- give trans-perineal template-guided mapping biopsy for participants suspected prostate cancer
- interventionNames
- Procedure: trans-perineal template-guided mapping biopsy
Primary outcomes (1)
- measure
- the spatial distribution based on the biopsy tissue
- timeFrame
- 2 years
- description
- to simulate the spatial distribution of cancer based on the biopsy tissue contained cancer with the help of TPS system
Secondary outcomes (1)
- measure
- the spatial distribution based on the large tissue slice technique
- timeFrame
- 2 years
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 18 Years
- Maximum age
- 90 Years
Show eligibility criteria text
Inclusion Criteria: 1.Male patients; 2.18 yrs and older, and 90 yrs and younger; 3.Rectal examination reveal prostate nodules; 4.B ultrasound, CT or MRI find abnormal images; 5.PSA\>4ng/ml, abnormal f/t ratio and PSAD Exclusion Criteria: 1. Abnormal coagulation function; 2. Severe urinary tract infection; 3. Serious cardiovascular and cerebrovascular disease
References
Publications (1)
- BACKGROUNDTran M, Thompson J, Bohm M, Pulbrook M, Moses D, Shnier R, Brenner P, Delprado W, Haynes AM, Savdie R, Stricker PD. Combination of multiparametric MRI and transperineal template-guided mapping biopsy of the prostate to identify candidates for hemi-ablative focal therapy. BJU Int. 2016 Jan;117(1):48-54. doi: 10.1111/bju.13090. Epub 2015 May 11. PMID 25682968