Clinical trial · Observational
Long-term Cancer Risk in the Randomised Oslo Diet and Antismoking Study
The Effect of Lifestyle Intervention on the Risk of Cancer - A Study of Participants in the Oslo Diet and Antismoking Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study examines the effect of a five-year multifactorial lifestyle intervention in the Oslo diet and antismoking study on long-term cancer risk. In 1972-1973, 1232 men with high cardiovascular risk profile were randomised to intervention including cholesterol lowering diet, weight loss and antismoking advice, or control (1:1). This study examines the effect of the intervention on 43-year cancer incidence and mortality.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Gastrointestinal Cancer | Malignant Digestive System Neoplasm | ALIAS | 0.90 |
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Prostate Cancer | Malignant Prostate Neoplasm | CURATED_EXACT | 0.92 |
| Urinary Tract Cancer | Malignant Urinary Tract Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Diet and antismoking advice | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Diet and antismoking advice
- description
- Dietary and antismoking advice, aiming to reduce participant's risk of cardiovascular diseases
- interventionNames
- Behavioral: Diet and antismoking advice
- label
- Control
- description
- No intervention
Primary outcomes (1)
- measure
- Incidence of the group of cancers related to smoking, diet or body mass index
- timeFrame
- 43 years
- description
- Diagnosis of carcinoma in the oral cavity, oropharynx, esophagus, stomach, colorectum, liver and intrahepatic bile ducts, pancreas, larynx, trachea, bronchus and lung, urinary tract and thyroid gland, drawn from the Cancer Registry of Norway
Secondary outcomes (7)
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 40 Years
- Maximum age
- 49 Years
Show eligibility criteria text
Inclusion Criteria: * participated in screening of coronary risk factors, into which all men born in 1923-1932 and living in Oslo were invited in 1972-1973 * being in the upper quartile of a coronary risk score based on blood pressure, serum total cholesterol concentration and cigarette smoking Exclusion Criteria: * serum total cholesterol level above 9.0 mmol per Liter * having a healthy diet, based on a short dietary history * self-reported cardiovascular disease or diabetes * previous history of cancer
References
Publications (0)
Data not yet available