Clinical trial · Observational
Mast Cell Activation Test in Allergic Disease
Assessment of Mast Cell Activation Diagnostic Test in Patients With Allergic Disease
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Activation of mast cells in the immune system is known to cause allergic reactions sometimes with severe systemic symptoms. The investigators have recently developed a blood-based mast cell activation diagnostic test in which levels of functional activation in-vitro in primary cultured mast cells generated from the peripheral blood of single individuals can be assessed. It is the hypothesis that the test can be used to predict the potential state of in-vivo mast cell activation in any individual based on the functional activation profiles exhibited by their cultured mast cells. The investigators now wish to translate their in-vitro findings in a pilot study to disease groups where mast cell activation is expected to be high. These include highly allergic individuals; those with chronic idiopathic urticaria; those with mastocytosis; and those with the mast cell activation syndrome. Furthermore, they will use the functional genomics approach to identify gene expression biomarkers that are correlated with such diseases. The results will be compared with data that have been collected from a cohort of healthy control blood donors.
Conditions
Conditions (7)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Anaphylaxis | — | UNRESOLVED | — |
| Asthma | — | UNRESOLVED | — |
| Chronic Idiopathic Urticaria | — | UNRESOLVED | — |
| Eczema | — | UNRESOLVED | — |
| Food Allergy | — | UNRESOLVED | — |
| Mast Cell Activation Syndrome | — | UNRESOLVED | — |
| Mastocytosis | Mastocytosis | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (7)
- label
- urticaria
- description
- Patients with this condition
- label
- asthma
- description
- Patients with this condition
- label
- eczema
- description
- Patients with this condition
- label
- food allergy
- description
- Patients with this condition
- label
- anaphylaxis
- description
- Patients with this condition
- label
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: Any patients with the above diagnoses - Exclusion Criteria: Children \< 18 years old; those who are unwilling or unable to donate blood; pregnant mothers. \-
References
Publications (1)
- BACKGROUNDTam IYS, Ng CW, Tam SY, Lau HYA. Novel six-week protocol for generating functional human connective tissue-type (MCTC) mast cells from buffy coats. Inflamm Res. 2017 Jan;66(1):25-37. doi: 10.1007/s00011-016-0989-z. Epub 2016 Sep 15. PMID 27628164