Clinical trial · Observational
Prognosis and Therapeutic Biomarkers for Glioblastoma Patients
NCT03403803CI-TRIAL-00037820terminatedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Were not able to meet enrollment goal due to inclusion/exclusion criteria
Summary
Brief summary (as posted)
The purpose of this study is to investigate if the potential biomarkers identified could be used for facilitating the diagnosis and prognosis of patients with glioblastoma (GBM).
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Glioblastoma | Glioblastoma | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Optune | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- label
- Control Group
- label
- Optune Only
- interventionNames
- Device: Optune
- label
- Optune and TMZ
- interventionNames
- Device: Optune
Primary outcomes (1)
- measure
- Primary Outcome - CD44 expression in cerebrospinal fluid (CSF), blood and saliva
- timeFrame
- 2 years
- description
- Currently, Glioblastoma is only diagnosed and monitored with brain scans. Expression levels of CD44 along with CD133, ABCC3, TNFRSF1A, AKT1, IDH2 and MGMT in samples of CSF, blood and saliva from patients receiving different types of treatment and comparing them with non-GBM patients (control group) will be tested.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 22 Years
Show eligibility criteria text
Inclusion Criteria: * 22 years old * Control Group (only patients evaluated for neurological disorders whose evaluation require a lumbar puncture) * Non-Control Group - Diagnosed with GBM (Glioblastoma) Exclusion Criteria: * Pregnancy * Infectious Disease to include cold, flu, HIV, etc. * Blood Disorder (example:low platelets, anemia, thrombosis) * Vascular Malformations
References
Publications (0)
Data not yet available
No reference posted for this study.