Clinical trial · Interventional
Dual-Energy CT on Plan Quality, Dose-delivery Accuracy, and Simulated Outcomes of Patients Treated With Proton or Photon Therapy
A Virtual Clinical Trial to Assess the Impact of Dual-Energy CT on Plan Quality, Dose-delivery Accuracy, and Simulated Outcomes of Patients Treated With Proton or Photon Therapy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Low accrual
Summary
Brief summary (as posted)
The aim of this protocol is to refine the accuracy of proton beam therapy (PT) by the use of dual energy computed tomography (DECT), in conjunction with novel iterative image reconstruction algorithms, to more precisely determine the tissue properties through which the proton beam path travels.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Cancer | Malignant Brain Neoplasm | ALIAS | 0.90 |
| Head and Neck Cancer | Malignant Head and Neck Neoplasm | ALIAS | 0.90 |
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Philips Brilliance Big Bore CT/simulator | Device | — | UNRESOLVED |
| Siemens Somatom Definition Edge | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Dual-Energy CT scan
- description
- Patients enrolling in this study will undergo additional sequential DECT scan in addition to their routine SECT or DECT scan.
- interventionNames
- Device: Siemens Somatom Definition Edge
- Device: Philips Brilliance Big Bore CT/simulator
Primary outcomes (1)
- measure
- Dose Difference in 99% Planning Target Volume (PTV) Coverage Between Single Energy CT and Dual Energy CT
- timeFrame
- Day 1
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Eligibility Criteria: Inclusion Criteria: * Diagnosis of histologically proven primary or metastatic cancer requiring thoracic radiation therapy OR radiation therapy to the head and neck or brain * At least 18 years of age. * Planning to undergo proton or photon beam radiation therapy as part of the clinical management of the diagnosed cancer. * Able to understand and willing to sign an IRB-approved written informed consent document. Exclusion Criteria: * Implanted metallic objects in the region to be scanned excepting dental prostheses * IV or oral contrast medium within 24 hours prior to DECT image acqusition * Pregnant.
References
Publications (0)
Data not yet available