Clinical trial · Interventional
PET CT Re-Planning NSCLC (4DCT-PET)
Prospective Study of CT and PET Imaging During a Course of Radical Radiotherapy to Determine the Dosimetric Benefits of Re-Planning in Non-Small Cell Lung Cancer
NCT03403127CI-TRIAL-00046639completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study will see whether the addition of more frequent planning CTs during the course of radiation, and of Positron Emission Tomography (PET), a diagnostic test similar to CT, prior to and during a course of radiation may provide information that could potentially be used during the treatment to improve the initial radiation plan.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Non-Small Cell Lung Cancer | Lung Non-Small Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| PET/CT Scans | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (8)
- measure
- GTV volumes
- timeFrame
- 2 weeks post RT treatment
- description
- The ratio of the GTV volumes defined using 4D CT (GTV4DCT) planning scans is a prognostic parameter for NSCLC.
- measure
- GTV volumes
- timeFrame
- 4 weeks post RT Treatment
- description
- The ratio of the GTV volumes defined using 4D CT (GTV4DCT) planning scans is a prognostic parameter for NSCLC
- measure
- GTV volumes
- timeFrame
- 7 weeks post RT Treatment
- description
- The ratio of the GTV volumes defined using 4D CT (GTV4DCT) planning scans is a prognostic parameter for NSCLC
- measure
- GTV volumes
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age equal to or more than 18 years old * Patients with NSCLC consenting for radiotherapy to the primary tumor and / or mediastinal / hilar lymph nodes. Prescription doses should be 60Gy or higher. * Chemo-RT patients of any stage of NSCLC * Patients with a measurable tumor on CT scan. * Patients who are able to lie supine for two consecutive 25 minutes sessions. Exclusion Criteria: * Trimodality patients who will have surgery within 2 months post RT * Previous radiotherapy to intended treatment volumes. * Patients with recurrent disease * Active malignancy other than lung cancer * Pregnancy * Failure to provide written informed consent
References
Publications (0)
Data not yet available
No reference posted for this study.