Clinical trial · Interventional
The Diagnostic Value of 18F-FET PET/MRI for CNS Tumors in Children and Adolescents
NCT03402425CI-TRIAL-00037849BUFunknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
To investigate the diagnostic value of 18F-FET PET/MRI instead of MRI alone, children and adolescents with tumor in brain or spinal cord are included and scanned primarily at our hybrid PET/MRI using the amino acid analog 18F-FET. The scans are performed at primary diagnosis, before radiation therapy, before and after operation, when relapse is suspected and three or six months after initiation of chemotherapy.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Neoplasms, Childhood | Childhood Brain Neoplasm | ALIAS | 0.90 |
| Positron-Emission Tomography | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 18F-FET PET | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- All included patients
- description
- A 18F-FET PET scan is performed
- interventionNames
- Diagnostic Test: 18F-FET PET
Primary outcomes (1)
- measure
- Change of treatment
- timeFrame
- up to 3 months
- description
- The treatment plan is changed based on the PET findings
Secondary outcomes (2)
- measure
- Sensitivity and specificity
- timeFrame
- up to 3 months
- description
- The sensitivity and specificity of PET/MRI is compared to MRI alone. The gold standard is clinical follow-up.
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Suspicion of newly diagnosed CNS tumor, recurrence or radiation therapy planning * age \<18 years at first CT/MRI suggesting CNS tumor * written informed consent from parents (age \< 18 years) or the patient (age \>18 years) Exclusion Criteria: * contraindications for MRI (e.g. metal implants) * pregnancy * known syndrome with increased sensitivity to radiation (e.g. Gorlin or Ataxia Telangiectasia
References
Publications (0)
Data not yet available
No reference posted for this study.