Intervention of Ovarian Cancer With Antigen-specific Engineered Immune Effectors

Inclusion Criteria:

1. Written, informed consent obtained prior to any study-specific procedures.
2. Age older than 10 years.
3. Eastern Cooperative Oncology Group (ECOG) PS of 0 or 1.
4. Expected survival ≥ 12 weeks.
5. Histologically confirmed and documented high risk International Federation of Gynecology and Obstetrics (FIGO): Stage II-IV.
6. Not pregnant, and on appropriate birth control of childbearing potential.
7. Initial hematopoietic reconstitution with

   * neutrophils (ANC) ≥ 1,000/mm\^3;
   * platelet (PLT) ≥ 100,000/mm\^3.
8. Proper renal and hepatic functions (ULN denotes "upper limit of normal range") with

   * serum creatinine ≤ 2×ULN;
   * serum bilirubin ≤ 2×ULN;
   * AST/ALT ≤ 2×ULN;
   * ALKP ≤ 5×ULN;
   * serum bilirubin. 2.0 is acceptable in the setting of known Gilbert's syndrome.
9. Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) test negative.

Exclusion Criteria:

1. Patients with ovarian tumors with low malignant potential (i.e. borderline tumors);
2. Patients with evidence of abdominal free air not explained by paracentesis or recent surgical procedure (prior, current or planned treatment).
3. Prior treatment of any adoptive T cell therapy.
4. Current or recent treatment (within the 14-day period prior to Day 0) with any immune suppressive drug
5. Minor surgical procedures within 2 days prior to Day 0 (including central venous access device placement for chemotherapy administration, tumor biopsies, needle aspirations).
6. Pregnant or lactating females.
7. Inadequate bone marrow function with

   * absolute neutrophil count \< 1,000/mm\^3;
   * platelet count \< 100,000/mm\^3;
   * Hb \< 9 g/dL.
8. Inadequate liver and renal function with

   * serum (total) bilirubin \> 1.5 x ULN;
   * AST \& ALT \> 2.5 x ULN (\> 5 x ULN in patients with liver metastases);
   * alkaline phosphatase \> 2.5 x ULN;
   * serum creatinine \>2.0 mg/dl (\> 177 μmol/L);
   * urine dipstick for protein uria should be \< 2+. Patients with ≥ 2+ proteinuria on dipstick urinalysis at baseline should undergo 24 hour urine collection and must demonstrate \< 1 g of protein/24 hr.
9. Serious active infection requiring i.v. antibiotics
10. Subject infected with HCV (HCV antibody positive), or HIV (HIV antibody positive),Treponema pallidum antibody positive or TB culture positive.