Clinical trial · Observational
Pelvic Microbiomes of Benign and Malignant Ovarian Diseases
The Role of Pelvic Microbiomes During the Malignant Transformation of Benign Ovarian Diseases
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This case-control study aims to compare the pelvic microbiomes of benign ovarian diseases and ovarian malignancies by 16s RNA techniques and culture. Discharges/flushing fluid from vagina, faces and fimbria end of fallopian tube are collected from age and menopausal status matched patient before and during procedures of laparoscopies. The discharges/flushing fluid would be sent for 16s RNA analysis and microculture respectively, and the results would get self-contrasted comparison and case-control comparison.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Microbiota | — | UNRESOLVED | — |
| Ovarian Neoplasms | Ovarian Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Ribosome Alteration | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| microbiomes | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Benign ovarian disease
- description
- The group consists of patients of benign ovarian diseases and health conditions (eg infertility), who would accept the tests of pelvic microbiomes.
- interventionNames
- Diagnostic Test: microbiomes
- label
- Malignant ovarian disease
- description
- The group consists of patients of high grade serous carcinoma, who would accept the tests of pelvic microbiomes.
- interventionNames
- Diagnostic Test: microbiomes
Primary outcomes (2)
- measure
- Difference of species distribution of microorganism according to 16s RNA analysis
- timeFrame
- 2 years
- description
- The difference of species of microorganism distribution according to 16s RNA sequencing analysis between control group and study group, and between different sampling sites in each arm
Eligibility
Eligibility (as posted)
- Sex
- Female
Show eligibility criteria text
Inclusion Criteria: * Laparoscopy procedures * Specific pathological diagnosis Exclusion Criteria: * Previous history of pelvic surgeries * Evidences of pelvic inflammation diseases
References
Publications (0)
Data not yet available