Clinical trial · Observational
Gut Mucosal Microbiota is Associated With Colorectal Cancer Relapse
Structural of the Gut Mucosal Microbiota is Associated With Colorectal Cancer Relapses After Curative Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Colonic microbiome has been found to contribute to the development of colorectal cancer. We speculate that gut microbiota related to colorectal cancer relapse after curative treatment. This study aim to discover if any difference of gut microbiota exist in patients who suffer from cancer relapse compared with patients who do not. Finally develop patient-centred programmes of surveillance protocols base on microbiota analysis.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Gut Microbiota | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- Relapse
- description
- Patients who suffered colorectal cancer relapse after curative surgery
- label
- Remission
- description
- Patients who get remission after curative surgery
Primary outcomes (1)
- measure
- Transcriptional changes in gut microbiota
- timeFrame
- Baseline, 6 months after surgery, 12 months after surgery, 24 months after surgery
- description
- 16S rRNA gene sequencing will be performed with stander procedure
Secondary outcomes (1)
- measure
- Epigenetic changes
- timeFrame
- Baseline, 6 months after surgery, 12 months after surgery, 24 months after surgery
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 35 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Requirements of informed consent and assent of participant, parent or legal guardian as applicable * Patients with colorectal cancer scheduled for radical coloproctectomy and between the age of 18 and 75 years old without considering sex. * Patients with BMI= 18.5-23.9 * Participants can follow the visit plan Exclusion Criteria: * Patients with colorectal cancer with distant metastasis * Chronic renal diseases and hepatic cirrhosis * Chronic ischemic heart disease with unstable angina, chronic heart failure at class III or IV and acute myocardial infarction in the last 6 months * Individuals with a history of Chronic diarrhea * Individuals with a history of Diabetes mellitus * Individuals with a history of Hypertension * Individuals with a history of autoimmune diseases * Use of antibiotics and probiotics 3 mouth before samples collection * Individuals with a history of abdominal operation due to any reason * Individuals with any history of cancer other than colorectal cancer * Individuals with Inflammatory bowel disease
References
Publications (0)
Data not yet available