Clinical trial · Observational
Gut Microbiota Prediction of Metachronous Colorectal Neoplasms
Gut Microbiota Prediction of Metachronous Colorectal Neoplasms in Patients With Colorectal Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Patients with colorectal cancer are known to be at high risk of developing metachronous adenoma, however, participation in colonoscopy are low. Colonoscopy, the primary modality used all over the word, is costly and invasive, and its efficacy depends on the endoscopist's skill and the patient's bowel preparation. As life expectancy of patients with history of colon cancer is increasing, colonoscopy would increase the overall cost for patients and for the health care system. This study aim to construct a predictive model of postoperative colorectal neoplasm development using microbiota analysis.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gut Microbiota | — | UNRESOLVED | — |
| Metachronous Adenoma | Adenoma | CURATED_BROADER | 0.78 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (4)
- label
- Observation group 1
- description
- Patients who suffered metachronous adenoma after proximal colorectum cancer surgery.
- label
- Control group 1
- description
- Patients who do not suffere metachronous adenoma after proximal colorectum cancer surgery.
- label
- Observation group 2
- description
- Patients who suffered metachronous adenoma after distal colorectum cancer surgery.
- label
- Control group 2
- description
- Patients who do not suffered metachronous adenoma after distal colorectum cancer surgery.
Primary outcomes (1)
- measure
- Differences In Microbiota
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 35 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Requirements of informed consent and assent of participant, parent or legal guardian as applicable * Patients who underwent exhaustive colorectal cancer surgical resection and accept colonoscopy * Patients between the age of 35 and 75 years old without considering sex * Patients with BMI= 18.5-23.9 * Participants can follow the visit plan Exclusion Criteria: * Patients with colorectal cancer with distant metastasis * Chronic renal diseases and hepatic cirrhosis * Chronic ischemic heart disease with unstable angina, chronic heart failure at class III or IV and acute myocardial infarction in the last 6 months * Individuals with a history of Chronic diarrhea * Individuals with a history of Diabetes mellitus * Individuals with a history of Hypertension * Individuals with a history of autoimmune diseases * Use of antibiotics and probiotics 3 mouth before samples collection * Individuals with a history of abdominal operation due to any reason * Individuals with any history of cancer other than colorectal cancer * Individuals with Inflammatory bowel disease
References
Publications (0)
Data not yet available