Prostate Boost Irradiation With Stereotactic Body RT (SBRT)

Inclusion Criteria:

* Histological and or clinical diagnosis of high risk adenocarcinoma of the prostate within six months of entry (stage T3 or higher and/or Gleason score 8 or higher and/or initial PSA level above 20;)
* No radiographic evidence of metastatic disease to the abdomen, lymph nodes, bone or other distant organs; determined by standard staging investigations (bone scan and CT-scan of the abdomen and pelvis) or incidental findings (localized N0, M0 disease)
* Patient is able to complete the quality of life questionnaires in English.
* Informed consent obtained

Exclusion Criteria:

* • Histological diagnosis of carcinoma of the prostate more than six months prior to potential registration date;
* Previous treatment for carcinoma of the prostate (other than biopsy or TURP), including bilateral orchiectomy;
* Patients previously on more than twelve weeks of hormone therapy for their PrCa;
* Past history of other malignancies except: adequately treated non-melanoma skin cancer or other solid tumours curatively treated with no evidence of disease for more than 3 years;
* Contraindications to placement of gold seeds for daily prostate localization;
* Previous pelvic RT and/or significant pelvic surgery;
* Severe diverticular or inflammatory bowel disease (as determined by the treated radiation oncologist)
* Previous hip replacement
* PSA over 50
* IPSS 20 or higher
* TRUS-based prostate
* volume of \> 80 cc