Clinical trial · Interventional
A Multicenter Trial of PLA vs. Surgery for Treating PTMC
A Multicenter Prospective Controlled Trial of Laser Ablation Versus Surgery for the Treatment of Papillary Thyroid Microcarcinoma
NCT03377829CI-TRIAL-00050784unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a multicenter prospective controlled trial of percutaneous laser ablation(PLA) versus conventional surgery for the treatment of papillary thyroid microcarcinoma (PTMC).
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Thyroid Cancer | Malignant Thyroid Gland Neoplasm | CURATED_EXACT | 0.92 |
| Treatment Related Cancer | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| PLA | Procedure | — | UNRESOLVED |
| Thyroid Surgery | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Percutaneous laser ablation(PLA)
- description
- Eligible participants with PTMC will be randomly assigned to this group and undergo percutaneous laser ablation(PLA). All the process is under the detection of real-time ultrasound.After surgery, all the patients will accept contrast-enhanced ultrasound(CEUS), regular ultrasound follow-up, thyroid functional detection, fine-needle aspiration biopsy(FNAB), neck CT.Per and post-operative complications, need of drug treatment, length of hospital admission and customer satisfaction will be registered.
- interventionNames
- Procedure: PLA
- type
- ACTIVE_COMPARATOR
- label
- Surgery
- description
- Eligible participants with PTMC will be randomly assigned to this group and undergo total/subtotal thyroid surgery.
- interventionNames
- Procedure: Thyroid Surgery
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Newly diagnosed PTMC (maximun diameter\> = 5 mm and \< = 10 mm) proved by fine needle aspiration biopsy with good thyroid function; * Age≥ 18 Y; * Single nodule without thyroid capsule contact; * There had more than 3mm distance between nodules and trachea, carotid artery, recurrent laryngeal nerve (The distance should up to 5mm after injection of isolation fluid); * No coarse calcification or eggshell-like calcification; * Imaging examination without local or distant metastasis; * Without chemotherapy, radiotherapy and other related therapies; * A complete clinical, pathological and follow-up information; * Get informed consent signed by the patient or family member. Exclusion Criteria: * Multifocal PTMC; * Combined with other types of thyroid cancer or hyperthyroidism; * Lesion contact with thyroid capsule or located in the isthmus; * Serious coagulation dysfunction; * Contralateral vocal cord paralysis; * Imaging examination with local or distant metastasis; * Active Tuberculosis and HIV-positive patients; * Patients can not understand or follow research protocol; * Pregnant woman.
References
Publications (0)
Data not yet available
No reference posted for this study.