Allogeneic Myeloma GM-CSF Vaccine With Lenalidomide in Multiple Myeloma Patients in Complete or Near Complete Remission

Inclusion Criteria:

* Myeloma eligibility criteria are the following:
* Near complete remission (nCR) for ≥ 3 months defined as no measurable M-spike, and a positive serum immunofixation

  * For patients with a light chain only myeloma, they will be in deemed to be in a CR if they meet criteria for CR by International Myeloma Working Group (IMWG) consensus criteria 2016.
  * For patients with a light chain only myeloma that meet criteria for Very Good Partial Response (VGPR) by IMWG consensus criteria 2016 and are IFE -ve (negative serum immunofixation), they will be considered to be in a near complete remission (nCR).
* Or complete remission (CR) (no measurable M-spike, immunofixation negative and bone marrow plasma cells \<5%)
* NDMM or RMM in nCR or CR having completed a minimum of 6 cycles of a lenalidomide based regimen for a minimum of ≥ 3 months
* NDMM or RMM a patients who have been off corticosteroids for ≥ 4 weeks
* Patients with NDMM or RMM who have had autologous stem cell transplant are eligible, but must be ≥ 12 months from transplant
* All patients must be MRD positive at 10-4 or greater by NGS sequencing at enrollment
* All patients must be currently taking Revlimid at screening.
* Age \>18 years
* ECOG performance scores 0-2
* History of measurable serum or urine M protein or free light chains
* Life expectancy greater than 12 months
* Corrected serum calcium \< 11 mg/dL, and no evidence of symptomatic hypercalcemia
* Serum creatinine\< 2 mg/dl
* ANC \>1000/µL
* Platelet \>100,000/µL
* Total bilirubin \<= 1.5 x ULN
* AST (SGOT) and ALT (SGPT) \<= 3 x ULN.
* Ability to comprehend and have signed the informed consent.
* Have previously agreed to continue on maintenance therapy with lenalidomide concurrent with vaccine administration until disease progression, or clinical indication to cease therapy.
* Disease free of prior malignancies for at least 5 years with exception of currently treated basal cell or squamous cell carcinoma of the skin, or carcinoma "in situ" of the uterus, cervix or breast.
* All study participants must be registered into the mandatory Revlimid REMS® program, and be willing and able to comply with the requirements of the REMS® program.
* Females of reproductive potential must adhere to the scheduled pregnancy testing as required in the Revlimid REMS® program.
* Females of childbearing potential (FCBP) must have a negative serum or urine pregnancy test with a sensitivity of at least 50 mIU/mL within 10 - 14 days prior to starting lenalidomide with each cycle (prescriptions must be filled within 7 days) and must either commit to continued abstinence from heterosexual intercourse or begin TWO acceptable methods of birth control, one highly effective method and one additional effective method AT THE SAME TIME, at least 28 days before she starts taking lenalidomide. FCBP must also agree to ongoing pregnancy testing. Men must agree to use a latex condom during sexual contact with a FCBP even if they have had a successful vasectomy.
* Able to take prophylactic anticoagulation (aspirin 81 or 325 mg/daily or, for patients intolerant to ASA, warfarin or low molecular weight heparin).

Exclusion Criteria:

* Disease progression after stopping corticosteroids as defined as the appearance of a detectable serum or urine M-spike, or an absolute increase of \>10 mg/dl between involved and uninvolved light chains, in the absence of measurable serum or urine M-protein .
* Patients who are MRD negative by NGS at screening.
* Patients with a known diagnosis of POEMS syndrome, plasma cell leukemia, CNS involvement, non-secretory myeloma and amyloidosis
* High-risk myeloma defined by presence of at least one of the following defining features on initial diagnostic, or most recent bone marrow biopsy:
* High risk chromosomal translocations by FISH: t(4;14), t(14;16), t(14;20),
* del(17p), del(1p), amplification 1q.;
* MyPRS GEP-70 high risk signature either from diagnosis or at time of registration for the study;
* LDH \> 300 U/L at diagnosis;
* Relapse from prior therapy within 12 months.
* HIV disease, active infection requiring treatment with antibiotics, anti-fungal or anti-viral agents within 2 weeks of enrollment would be excluded from the study.
* Patients who have participated in any clinical trial, within the last four weeks, which involved an investigational drug.
* History of an active malignancy other than myeloma
* Autoimmune disease requiring active treatment.
* Known contra-indication to any component of allogeneic myeloma vaccine
* History of an allogeneic transplant