Clinical trial · Interventional
Volumetric Intensity Modulated Arc Therapy vs. Conventional Radiotherapy for Cancer Pain
A Phase II Randomized Controlled Trial of Volumetric Intensity Modulated Arc Therapy vs. Conventional Radiotherapy for Cancer Pain
NCT03374592CI-TRIAL-00062214completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study compares the use of conventional radiotherapy technique with volumetric intensity-modulated radiotherapy (VMAT) in the treatment of painful cancer metastases. Half of the patients will receive radiotherapy using a conventional technique, while the other half will receive their treatment using a the VMAT technique.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Neoplasm Metastasis | — | UNRESOLVED | — |
| Pain | — | UNRESOLVED | — |
| Quality of Life | — | UNRESOLVED | — |
| Radiotherapy Side Effect | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Conventional Radiotherapy | Radiation | — | UNRESOLVED |
| Volumetric Intensity-Modulated Arc Therapy | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Conventional Radiotherapy
- description
- 8Gy in 1 fraction or 20Gy in 5 fractions
- interventionNames
- Radiation: Conventional Radiotherapy
- type
- EXPERIMENTAL
- label
- Volumetric Intensity-Modulated Arc Therapy
- description
- 8Gy in 1 fraction or 20Gy in 5 fractions
- interventionNames
- Radiation: Volumetric Intensity-Modulated Arc Therapy
Primary outcomes (1)
- measure
- Quality of Life (QOL)
- timeFrame
- 1 week
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: 1. Pain (SF-BPI score ≥1) should be related to metastases (bone or others) or to the tumor itself 2. Capable of providing the full list of analgesic medication being used 3. Capable of completing the SF-BPI and EORTC questionnaires without any help 4. Life expectancy of at least 3 month 5. KPS greater or equal to 50 6. Radiotherapy to 1 site pain 7. Site of treatment not previously irradiated 8. No planned changes in analgesic within 7 days before and after treatment • Patient may be started on Dexamethasone on the first day of radiotherapy 9. No planned chemotherapy, radiotherapy or surgery within 7 days before and after treatment 10. Patient provided informed consent to participate in this study Exclusion Criteria: 1. Major mental or psychiatric impairments, which in the investigator's opinion will prevent administration or completion of the protocol therapy and/or interfere with follow-up. 2. Treatment to upper and lower limb 3. Treatment to 2 or more sites of pain 4. Re-irradiation of the site of treatment 5. Women who are pregnant 6. Life expectancy less than 3 month
References
Publications (2)
- RESULTWong P, Lambert L, Thanomsack P, Coulombe G, Lambert C, Charpentier AM, Barkati M, Fortin I, Lafontaine J, Roberge D. Quality of Life: A Prospective Randomized Trial of Palliative Volumetric Arc Therapy Versus 3-Dimensional Conventional Radiation Therapy. Int J Radiat Oncol Biol Phys. 2021 Apr 1;109(5):1431-1439. doi: 10.1016/j.ijrobp.2020.11.061. Epub 2020 Nov 28. PMID 33259935
- RESULTDorion V, Lambert L, Frazzi A, Cayer JF, Wong P. A Pilot Study in the Use of Activity Trackers for Assessing Response to Palliative Radiotherapy. Cureus. 2017 Nov 22;9(11):e1871. doi: 10.7759/cureus.1871. PMID 29383293