Clinical trial · Observational
Age-Related Eye Disease Study 2 (AREDS2) 10-year Follow-On
Age-Related Eye Disease Study 2 (AREDS2) 10-Year Follow-On Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Background: Age-related macular degeneration (AMD) and cataracts are two eye diseases. They were studied in the Age-Related Eye Disease Study (AREDS2) and the AREDS2 Follow-On study. These studies followed the natural course of the diseases. They also provided data on the long-term effects of certain oral supplements on AMD. Objective: To study the long-term effects of oral supplements on several things. These include incidences of lung cancer, development of late AMD, cataract surgery, cognitive function, and cardiovascular events. Eligibility: Former AREDS2 and AREDS2 Follow-On participants Design: Participants will have 1 visit. It will include: An eye exam that tests how well participants can see, measures eye pressure, and checks eye movements. The pupil will be dilated with eye drops. Pictures will be taken of the retina and the inside of the eye. Participants will grip a device in their hand to measure their grip strength. A blood sample will be taken. This will be stored for future genetic research. Cells may be created from the sample. A small sample of skin will be taken. Sponsoring Institution: National Eye Institute
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| AMD | — | UNRESOLVED | — |
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Cataract | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (1)
- label
- 1
- description
- Former AREDS2 and AREDS2 Follow-On participants
Primary outcomes (1)
- measure
- The incidence of advanced AMD, cataract surgery and lung cancer will be the primary outcomes of the study.
- timeFrame
- Study Completion
Secondary outcomes (1)
- measure
- Participant reports of incident cardiovascular events will be collected as secondary outcomes.
- timeFrame
- Study Completion
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 50 Years
Show eligibility criteria text
* INCLUSION CRITERIA: To participate in this study, the potential participant must meet all of the following criteria: 1. Previously enrolled in the AREDS2 and AREDS2 Follow-on protocols. 2. Participant must be offered sufficient opportunity to review and to understand the informed consent form, agree to the form s contents and provide written informed consent. EXCLUSION CRITERIA: There are no Exclusion Criteria.
References
Publications (0)
Data not yet available