Haploidentical NK Cells After Pemetrexed in Patients With Stage IV Non-Small Cell Lung Cancer (NSCLC)

Inclusion Criteria:

* Patients with histologically confirmed non-small cell lung cancer stage 4 (by AJCC 7th)
* Age, 20 years of age or older
* ECOG performance status, 0-2
* Life expectancy ≥3 months
* Patients should have at least one measurable lesion according to RECIST Criteria v1.1
* Failure after primary systemic treatment with a regimen including platinum-containing agent (primary systemic treatment may be adjuvant chemotherapy or chemo-radiotherapy, given within 12 months)
* Adequate bone marrow function (Hb ≥9 g/dL; ANC ≥1,500/uL; and platelet count ≥75,000/uL)
* Adequate renal function (serum creatinine \<1 x ULN or CLcr ≥45 mL/min by Cockroft and Gault formula
* Adequate liver function (total bilirubin \<1.5 x ULN; AST and ALT \<3 x ULN; and ALP \<3 x ULN, unless there is bone metastases without evidence of liver disease)
* Patients should have a suitable HLA-haploidentical family member who is willing to donate hematopoietic stem cells
* Patients should sign informed consent voluntarily

Exclusion Criteria:

* Patients who received anti-cancer chemotherapeutic or biological agents within 3 weeks. Patients who received anti-cancer treatment and did not recover from toxicities to grades 0-1 by NCI CTC AE ver 4.0 are not eligible as well.
* Patients with contraindication for any medication planned to be administered in the study
* Patients with significant fluid accumulation in third space (for example, pleural or pericardial effusion) that can not be controlled by drainage
* Active infectious process
* Inability to discontinue aspirin over 1.3 g daily or other NSAIDs. Patients cannot take aspirin or NSAIDs within 5 days of pemetrexed administration
* Major surgery within 4 weeks of study participation
* Palliative radiation therapy within 1 week of study participation
* Acute myocardial infarction within 6 months of study participation. History of uncontrolled arrhythmia, symptomatic angina, or symptomatic heart failure
* Past or current history of CNS metastasis (with exception of those patients who completed treatment of CNS metastasis and not received steroid treatment or whole brain radiotherapy within 2 weeks of screening visit or not received gamma knife treatment within 1 week of screening visit)
* History of malignancy (other than skin basal cell carcinoma, carcinoma in situ of uterine cervix, or thyroid cancer) within 5 years
* Pregnant or lactating women. Child-bearing women who are not willing to avoid pregnancy by contraceptives
* Man not agreeing to contraceptive measures such as condom or abstinence (It is recommended that contraceptive measures be used until 6 months after pemetrexed treatment)
* Other serious illness or medical condition