Clinical trial · Observational
Pre-Screening Study to Identify MTAP Loss in Advanced Solid Tumors or Lymphoma
Identification of MTAP Deletion in Archival Tumor Tissue: A Pre-Screening Study in Subjects With Advanced Solid Tumors or Lymphoma
NCT03361358CI-TRIAL-00044022completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to identify subjects with advanced solid tumors or lymphoma in which the methylthioadenosine phosphorylase (MTAP) protein has been lost.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Advanced Solid Tumors | Solid Neoplasm | CURATED_BROADER | 0.80 |
| Lymphoma | Lymphoma | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Determination of MTAP status in tumors
- timeFrame
- From initiation of the Pre-Screen study until the Phase 1 study of AG-270 is activated at each study site, up to 9 months
- description
- Number of tumor tissue samples found to have or not have MTAP deletion, as assessed by IHC
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Be ≥18 years of age. 2. Have a histologically confirmed diagnosis of an advanced solid tumor (other than a primary CNS malignancy) or lymphoma. 3. Have archival tumor tissue that can be provided for assessment of MTAP deletion status. 4. Have given written informed consent to participate in this study. Exclusion Criteria: 1. Have a primary CNS malignancy (eg, GBM). 2. Have a medical or psychological condition deemed by the Investigator likely to interfere with the subject's ability to give informed consent or participate in the study.
References
Publications (0)
Data not yet available
No reference posted for this study.