Clinical trial · Observational
The QUebec Adipose and Lifestyle InvesTigation in Youth (QUALITY) Cohort
NCT03356262CI-TRIAL-00083189QUALITYactive not recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The QUebec Adipose and Lifestyle InvesTigation in Youth (QUALITY) Cohort study is a unique and comprehensive longitudinal study of 630 Caucasian children and their parents that was designed to investigate the natural history and determinants of childhood obesity and its cardiometabolic consequences.
Conditions
Conditions (9)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cardiovascular Risk Factor | — | UNRESOLVED | — |
| Diabetes Mellitus, Type 2 | — | UNRESOLVED | — |
| Diet Habit | — | UNRESOLVED | — |
| Lifestyle | — | UNRESOLVED | — |
| Metabolic Complication | — | UNRESOLVED | — |
| Obesity, Childhood | — | UNRESOLVED | — |
| Pediatric ALL | Childhood Acute Lymphoblastic Leukemia | ALIAS | 0.90 |
| Physical Activity | — | UNRESOLVED | — |
| Sedentary Lifestyle | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Body mass index (BMI)
- timeFrame
- Through study completion, 13 - 14 years post baseline
- description
- Weight (kg) and height (m) will be combined to report BMI in kg/m\^2 and transformed to z-scores using WHO standards
Secondary outcomes (8)
- measure
- Waist circumference
- timeFrame
- Through study completion, 13 - 14 years post baseline
- description
- Measured in centimeters, midway between the last floating rib and the iliac crest
- measure
- % body fat mass
- timeFrame
- Through study completion, 13 - 14 years post baseline
- description
- Measured using dual energy x-ray absorptiometry and combined as total body fat mass in kg / total body mass in kg \* 100
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 8 Years
- Maximum age
- 10 Years
Show eligibility criteria text
Inclusion Criteria: * Children aged 8-10 years at baseline; * Caucasian of Western European ancestry; * At least one obese biological parent (i.e., body mass index (BMI) ≥30 kg/m2 or waist circumference \>102 cm in men and \>88 cm in women, based on self-reported measurements of height, weight and waist circumference) * Both biological parents available to participate in the baseline assessment. Exclusion Criteria: * Children with a previous diagnosis of Type 1 or 2 diabetes; * Children with a previous diagnosis of a serious illness, psychological condition, or cognitive disorder which hindered participation in some or all of the study components; * Children treated with anti-hypertensive medication or steroids (except if administered topically or through inhalation); * Children following a very restricted diet (\< 600 kcal/day); * Mother pregnant or breastfeeding at the baseline evaluation; * Family with pending plans to move out of the province of Quebec (Canada).
References
Publications (8)
- BACKGROUNDLambert M, Van Hulst A, O'Loughlin J, Tremblay A, Barnett TA, Charron H, Drapeau V, Dubois J, Gray-Donald K, Henderson M, Lagace G, Low NC, Mark S, Mathieu ME, Maximova K, McGrath JJ, Nicolau B, Pelletier C, Poirier P, Sabiston C, Paradis G. Cohort profile: the Quebec adipose and lifestyle investigation in youth cohort. Int J Epidemiol. 2012 Dec;41(6):1533-44. doi: 10.1093/ije/dyr111. Epub 2011 Jul 23. No abstract available. PMID 21785124
- DERIVEDSaade MB, Holden S, Kakinami L, McGrath JJ, Mathieu ME, Poirier P, Barnett TA, Beaucage P, Henderson M. Adiposity and cardiac autonomic function in children with a family history of obesity. Clin Auton Res. 2024 Dec;34(6):583-592. doi: 10.1007/s10286-024-01063-y. Epub 2024 Sep 21. PMID 39304555
- DERIVEDHarnois-Leblanc S, Van Hulst A, Lucibello KM, Harbec MJ, Sabiston CM, Maximova K, Sylvestre MP, Henderson M. Associations Between Weight-Loss Attempts, Weight-Related Stress, and Body Image During Childhood and Adolescence in Children With Parental Obesity. Child Obes. 2024 Sep;20(6):434-441. doi: 10.1089/chi.2023.0082. Epub 2024 Jan 19. PMID 38241489
- DERIVEDSohi DK, Van Hulst A, McNealis V, Simoneau G, Drapeau V, Barnett TA, Mathieu ME, Paradis G, Tremblay A, Benedetti A, Henderson M. Early Lifestyle Determinants of Adiposity Trajectories from Childhood into Late Adolescence. Child Obes. 2024 Jul;20(5):336-345. doi: 10.1089/chi.2023.0062. Epub 2023 Dec 13. PMID 38100098
- DERIVEDRoberge JB, Harnois-Leblanc S, McNealis V, van Hulst A, Barnett TA, Kakinami L, Paradis G, Henderson M. Body Mass Index Z Score vs Weight-for-Length Z Score in Infancy and Cardiometabolic Outcomes at Age 8-10 Years. J Pediatr. 2021 Nov;238:208-214.e2. doi: 10.1016/j.jpeds.2021.07.046. Epub 2021 Jul 21. PMID 34302856
- DERIVEDVan Hulst A, Paradis G, Harnois-Leblanc S, Benedetti A, Drapeau V, Henderson M. Lowering Saturated Fat and Increasing Vegetable and Fruit Intake May Increase Insulin Sensitivity 2 Years Later in Children with a Family History of Obesity. J Nutr. 2018 Nov 1;148(11):1838-1844. doi: 10.1093/jn/nxy189.