Clinical trial · Observational
Perioperative Symptom Study of Lung Cancer (CN-PRO-Lung 1)
An Observational Study for Establishing the Patient-reported Outcome-based Perioperative Symptom Management Cohort in Patients With Lung Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Investigators propose a multicenter prospective observational cohort study to develop and validate essential technical parameters for establishing the patient-reported outcome-based perioperative symptom management cohort in patients with lung cancer. With at least 300 patients with initial diagnosis of lung cancer and scheduled for surgery, this study will administer symptom assessments (MDASI-LC) and quality of life assessments (SIQOL) before surgery (typically within 3 days before surgery), daily after surgery (in hospital ≤ 14 days), and weekly after discharge, up to 4 weeks (±3 days) or the start day of postoperative oncologic treatment. In the upgraded research protocol, symptom and quality of life assessments (every 3 month for 1 year, every 6 month for 2-3 year, every 12 month for 4-5 year), as well as the follow-up of clinical outcomes will continue until 5 years after surgery.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Patient-reported Outcomes | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (1)
- label
- Lung cancer surgical patients
- description
- Patient-reported symptom assessments in patients undergoing lung cancer surgery.
Primary outcomes (1)
- measure
- Perioperative symptom burden (severity, freqency and impact on daily functioning) measured by MDASI-LC
- timeFrame
- less than 6 weeks
- description
- We will use MD Anderson Symptom Inventory lung cancer module (MDASI-LC) to longitudinally assess the perioperative symptom burden for lung cancer patients. The symptom burden will be profiled as symptom severity, frequency of moderate to severe symptom and its interference with daily functioning.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Be pathologically or clinically diagnosed as primary lung cancer before surgery; 2. Plan to undergo a surgical procedure. Exclusion Criteria: 1. Aged younger than 18; 2. Diagnosis of cognitive impairment or unable to understand the study requirements.
References
Publications (3)
- DERIVEDLiao J, Hu X, Wei X, Dai W, Yu H, Tian X, Wang Y, Qin Q, Xu N, Li Y, Li Q, Shi Q, Liu X. Sex-related differences in postoperative patient-reported outcomes among lung cancer patients: a multicenter cohort study. BMC Cancer. 2025 Apr 29;25(1):800. doi: 10.1186/s12885-025-14191-z. PMID 40301835
- DERIVEDWei X, Yu H, King-Kallimanis B, Liu Y, Huang L, Dai W, Yang D, Zhou X, Li Q, Shi Q. Long-Term Function Recovery Following Upper Versus Lower Lobectomy for Lung Cancer: A Multicenter Longitudinal Cohort Study. Thorac Cancer. 2025 Jan;16(1):e15505. doi: 10.1111/1759-7714.15505. Epub 2024 Dec 13. PMID 39670353
- DERIVEDDai W, Xie S, Zhang R, Wei X, Wu C, Zhang Y, Feng W, Liao X, Mu Y, Zhou H, Cheng X, Jiang Y, He J, Li Q, Yang X, Shi Q. Developing and validating utility parameters to establish patient-reported outcome-based perioperative symptom management in patients with lung cancer: a multicentre, prospective, observational cohort study protocol. BMJ Open. 2019 Oct 28;9(10):e030726. doi: 10.1136/bmjopen-2019-030726. PMID 31662377