Clinical trial · Interventional
Methadone Associated With Morphine for Cancer Pain
Analgesic Effect Evaluation of Methadone Associated With Morphine for Cancer Pain: Prospective Randomized Study
NCT03324815CI-TRIAL-00030119unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The study was prospective, randomized. Patients with cancer pain were evaluated, one group receiving methadone with morphine and another group receiving morphine as the only opioid. Pain intensity, total morphine dose and adverse effects were evaluated.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Methadone | Drug | — | UNRESOLVED |
| Morphine | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Morphine- Methadone
- description
- Morphine 5mg/6h plus metadone: 2,5mg/12h
- interventionNames
- Drug: Morphine
- Drug: Methadone
- type
- ACTIVE_COMPARATOR
- label
- Morphine
- description
- Morphine: 5mg/6h
- interventionNames
- Drug: Morphine
Primary outcomes (1)
- measure
- Opioid consumption
- timeFrame
- 3 months
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Approved by the Ethics Committee * signed the informed consent * cancer pain * starting the WHO thirth analgesic ladder, Exclusion Criteria: * cognitive impairment * psychiatric disease * illicit drug user * hypersensitivity to the study drugs * pregnant
References
Publications (1)
- DERIVEDDuarte FCN, Ferraro LHDC, Ferreira A, Sakata RK. A Randomized Controlled Trial Evaluating the Analgesic Effect of the Combination of Methadone With Morphine for Cancer Related Pain. Clin J Pain. 2021 Sep 1;37(9):664-668. doi: 10.1097/AJP.0000000000000959. PMID 34265791