Clinical trial · Interventional
Effects of Intraoperative GDFT on the Postoperative Brain Edema
Effects of Intraoperative Goal-directed Fluid Therapy (GDFT) on the Postoperative Brain Edema in Neurosurgical Patients With Malignant Supratentorial Gliomas
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Whether a fluid protocol aiming for protecting vital organ perfusion or fluid restriction is favorable to post-craniotomy outcomes such as brain edema remains uncertain. To our knowledge, there has been no extensive and quantitative analysis of brain edema following SVV-based GDFT in neurosurgical patients with malignant supratentorial glioma. So the study aims to observe the effect of the stroke volume variation-based GDFT on the postoperative brain edema and decrease the incidence of postoperative complications in neurosurgical patients with malignant supratentorial gliomas.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Edema | — | UNRESOLVED | — |
| Brain Tumor | Brain Neoplasm | ALIAS | 0.90 |
| Fluid Therapy | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| GDFT | Other | — | UNRESOLVED |
| traditional fluid therapy | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- GDFT group
- description
- The patients will receive fluid therapy under goal directed.
- interventionNames
- Other: GDFT
- type
- SHAM_COMPARATOR
- label
- Routine group
- description
- The patients will receive routine fluid therapy.
- interventionNames
- Other: traditional fluid therapy
Primary outcomes (1)
- measure
- Quantitative analysis of brain edema
- timeFrame
- Within 24 hours postoperatively
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: 1. Preoperative brain image indicating high-grade glioma (HGG), verified by postoperative histology of the World Health Organization (WHO) as grade III or IV tumors. 2. Age 18-65 years, and American Society of Anaesthesiologists (ASA) physical status I to III. 3. Signed informed consent. Exclusion Criteria: 1. Renal insufficiency or the creatinine clearance is \< 30 mL/kg. 2. Heart disease, New York Heart Association Functional Classification (NYHA) class II or higher heart failure, or if their cardiac ejection fraction is \< 20%. 3. Chronic obstructive pulmonary disease. 4. Extensive peripheral arterial occlusive disease. 5. Coagulopathy. 6. Surgery in the prone position. 7. Recurrent carcinoma or tumor in the brain ventricular. 8. Body Mass Index \<18.5 kg·m-2 or \>30.0 kg·m-2. 9. Awake craniotomy.
References
Publications (1)
- DERIVEDLiu X, Zhang X, Fan Y, Li S, Peng Y. Effect of intraoperative goal-directed fluid therapy on the postoperative brain edema in patients undergoing high-grade glioma resections: a study protocol of randomized control trial. Trials. 2022 Nov 19;23(1):950. doi: 10.1186/s13063-022-06859-9. PMID 36401274