Clinical trial · Interventional
Use of Human Dehydrated Amnion/Chorion (DHACM) Allograft in Partial Nephrectomy
A Single-Center Double Arm Single-Blinded Randomized Screening Clinical Trial to Evaluate the Use of Human Dehydrated Amnion/Chorion Membrane to Facilitate the Recovery of Renal Function Following Robotic Partial Nephrectomy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
After partial nephrectomy, kidney function decreases by about 10% overall and by about 20% in the operated kidney. This is primarily due to the loss of healthy parenchymal volume during resection of the tumor. In an effort to preserve and regenerate healthy parenchyma during the procedure and ultimately renal function after partial nephrectomy, the single center double arm single-blinded randomized screening clinical trial will evaluate the ability of human amnion/chorion allograft to facilitate the recovery of renal function following robotic partial nephrectomy.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Kidney Cancer | Malignant Kidney Neoplasm | CURATED_EXACT | 0.92 |
| Partial Nephrectomy | — | UNRESOLVED | — |
| Renal Function Aggravated | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dehydrated human amnion/chorion membrane | Other | — | UNRESOLVED |
| Standard of Care | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Treatment with DHACM
- description
- Partial nephrectomy patched with DHACM
- interventionNames
- Other: Dehydrated human amnion/chorion membrane
- type
- ACTIVE_COMPARATOR
- label
- Control without DHACM
- description
- Partial nephrectomy without DHACM.
- interventionNames
- Other: Standard of Care
Primary outcomes (1)
- measure
- Recovery of Renal Function
- timeFrame
- 12 months
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Any individual with a diagnosis of a renal mass. * All Patients undergoing partial nephrectomy as their definitive treatment for their renal mass. * Ability to understand and the willingness to sign a written informed consent. * Patients with a solitary clinical T1a renal mass. Exclusion Criteria: * Patients undergoing radical nephrectomy as their definitive treatment for their renal mass. * Patients with Transitional Cell Carcinoma. * Patients with known hereditary syndromes such Von Hippel-Lindau (VHL) syndrome, Lynch Syndrome, Birt-Hogg-Dube Syndrome. * Patients with metastatic disease undergoing cytoreductive nephrectomy as their definitive treatment for metastatic disease. * Patients with prior kidney surgery. * Patients with a solitary or horseshoe kidney. * Patients with a positive margin found during intra-operative frozen section done only when clinically indicated (i.e., macroscopic abnormality identified). * Patients with multiple renal masses. * Patients with greater than a clinical T1a renal mass.
References
Publications (0)
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