Clinical trial · Observational
Using Pleural Effusions to Diagnose Cancer
Clinical Identification of Malignant Pleural Effusions in the Emergency Department
NCT03319472CI-TRIAL-00042148MAPEDcompletedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Pleural effusions (PE) are common conditions that signal either infection or cancer. The investigators aim to develop, validate, and prospectively assess the MAPED score, a clinical score that predicts malignancy at admission. This tool will assist clinicians all over the world to rapidly assess the probability of an effusion being malignant within 4 hours of admission.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pleural Effusion | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (2)
- label
- Benign Pleural Effusion
- description
- Patients that will be diagnosed within a month from admission with any non-malignant cause of pleural effusion, including but not limited to effusions caused by common or tuberculous or fungal infection, heart failure, etc. Documentation of the etiology will be required for inclusion in this group, including but not limited to bacteriology, virology, PCR, radiology, heart echocardiogram or catheterization, as appropriate.
- label
- Malignant Pleural Effusion
- description
- Patients that will be diagnosed within a month from admission with any malignant cause of pleural effusion, including but not limited to effusions caused by lung, breast, colon, ovary, mesothelial, hematopoietic, prostate, or any other cancer. Diagnosis will be based on verification of the presence of malignant cells in the pleural fluid or tissues. Patients with cancer and an effusion without such documentation will be assigned to the benign group if an alternative diagnosis is made. In any other case, they will be excluded.
Primary outcomes (1)
- measure
- Diagnosis of Malignancy
- timeFrame
- One month post-admission
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Pleural effusion * Hospital admission * No previous pleural procedure * Age \> 18 years * No previous chemoradiotherapy * No antibiotic therapy during previous trimester * All history, chest X-ray, and pleural and blood cell counts and biochemistry entry data obtained within 4 hours after admission Exclusion Criteria: * No diagnosis at one month post-admission * No informed consent provided * Age \< 18 years * History, chest X-ray, or pleural and blood cell counts and biochemistry entry data obtained later than 4 hours after admission
References
Publications (0)
Data not yet available
No reference posted for this study.