Clinical trial · Interventional
Rehabilitative Strategies Following Oesophageal Cancer
NCT03314311CI-TRIAL-00029970ReStOrecompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The ReStOre trial is a multi-disciplinary intervention of exercise, diet and education for patients who have completed treatment for oesophageal cancer. The intervention aims to improve quality of life and functional performance following oesophageal cancer and assist patients to return to normal activity during the early survivorship phase. The 12-week intervention will involve structured exercise training, individual dietary advice and multi-disciplinary education sessions addressing a range of survivorship needs.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Esophageal Cancer | Malignant Esophageal Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Rehabilitation programme | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Rehabilitation Programme
- description
- 12 week multi-disciplinary intervention prescribing exercise, individual dietary counselling and education sessions.
- interventionNames
- Behavioral: Rehabilitation programme
- type
- NO_INTERVENTION
- label
- Control
- description
- Usual care control arm
Primary outcomes (1)
- measure
- Change in Aerobic Fitness
- timeFrame
- Change from baseline in aerobic fitness at 12 weeks (end of intervention)
- description
- Aerobic fitness (ml/kg/min) will be measured by maximal cardiopulmonary exercise test
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Patients who have completed treatment for oesophageal cancer to include oesophagectomy. Patients may have also been treated with neo-adjuvant or adjuvant chemotherapy or chemoradiotherapy. * Curative treatment intent. * Age \>18 years * Able to understand English Exclusion Criteria: * Evidence of active or recurrent disease
References
Publications (2)
- DERIVEDKennedy SA, Annett SL, Dunne MR, Boland F, O'Neill LM, Guinan EM, Doyle SL, Foley EK, Elliott JA, Murphy CF, Bennett AE, Carey M, Hillary D, Robson T, Reynolds JV, Hussey J, O'Sullivan J. Effect of the Rehabilitation Program, ReStOre, on Serum Biomarkers in a Randomized Control Trial of Esophagogastric Cancer Survivors. Front Oncol. 2021 Sep 15;11:669078. doi: 10.3389/fonc.2021.669078. eCollection 2021. PMID 34604026
- DERIVEDO'Neill LM, Guinan E, Doyle SL, Bennett AE, Murphy C, Elliott JA, O'Sullivan J, Reynolds JV, Hussey J. The RESTORE Randomized Controlled Trial: Impact of a Multidisciplinary Rehabilitative Program on Cardiorespiratory Fitness in Esophagogastric cancer Survivorship. Ann Surg. 2018 Nov;268(5):747-755. doi: 10.1097/SLA.0000000000002895. PMID 30004915