Clinical trial · Interventional
Comparing Efficacy of Postoperative Oral Antibiotic Use in Trans-Oral Thyroidectomy
Comparing Efficacy of Postoperative Antibiotic Use in Transoral Thyroidectomy: a Prospective Randomized Controlled Trial Study
NCT03295955CI-TRIAL-00029702POTOunknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Transoral endoscopic thyroid surgery is a emerging surgical technique for thyroid surgery. This study to investigate the need for postoperative antibiotics in transoral endoscopic thyroid surgery.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Surgical Wound Infection | — | UNRESOLVED | — |
| Thyroid Nodule | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Amoxicillin Clavulanate | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Postop antibiotics group
- description
- Prescribe Amoxicillin Clavulanate
- interventionNames
- Drug: Amoxicillin Clavulanate
- type
- NO_INTERVENTION
- label
- No postop antibiotics
- description
- Do not prescribe Amoxicillin Clavulanate
Primary outcomes (2)
- measure
- "CDC 1992 SSI table" score
- timeFrame
- Postoperative 1 day
- description
- Clinical evidence of Surgical Site Infection
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * Patients who planned to Transoral endoscopic thyroidectomy * Age between 20 to 70 * Voluntarily consenting to the study and study agreement * No local invasion or distant metastasis * Normal vocal cord function in laryngoscopic exam * No significant abnormalities in preoperative laboratory tests Exclusion Criteria: * Take aspirin or antiplatelet drugs within 7 days before admission * Uncontrolled hypertension, diabetes, chronic renal failure, or coagulation disease * History of cardiovascular disease (angina pectoris, heart failure, myocardial infarction, history of coronary artery disease, stroke, transient ischemic attack) * Substance abuse and alcohol abuse * History of esophageal and airway diseases * Patient was participated in other clinical trials within 30 days * History of neck irradiation or surgery * History of drug allergies * Pregnant or lactating women
References
Publications (3)
- RESULTAnuwong A, Ketwong K, Jitpratoom P, Sasanakietkul T, Duh QY. Safety and Outcomes of the Transoral Endoscopic Thyroidectomy Vestibular Approach. JAMA Surg. 2018 Jan 1;153(1):21-27. doi: 10.1001/jamasurg.2017.3366. PMID 28877292
- RESULTAnuwong A. Transoral Endoscopic Thyroidectomy Vestibular Approach: A Series of the First 60 Human Cases. World J Surg. 2016 Mar;40(3):491-7. doi: 10.1007/s00268-015-3320-1. PMID 26546193
- DERIVEDYi JW, Kim SJ, Lee KE. Evaluation of the efficacy of postoperative antibiotic treatment in transoral endoscopic thyroidectomy: a prospective randomised controlled trial. Br J Oral Maxillofac Surg. 2020 Apr;58(3):334-340. doi: 10.1016/j.bjoms.2020.01.004. Epub 2020 Jan 22. PMID 31982170