Clinical trial · Interventional
Risk-Reducing Surgeries for Hereditary Ovarian Cancer
Risk-Reducing Surgeries of Salpingo-oophorectomy With/Without Hysterectomy for Carriers With Mutation Genes of Hereditary Ovarian Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Based on studies of "Inherited Susceptible Genes Among Epithelial Ovarian Cancer" (NCT03015376, clinicaltrials.gov) and "Cohort Study of Universal Screening for Lynch Syndrome in Chinese Patients of Endometrial Cancer" (NCT03291106, clinicaltrials.gov), we provide risk-reducing surgeries of salpingo-oophorectomy with/without hysterectomy for healthy carriers with mutation genes of hereditary ovarian cancer, which is defined ovarian cancer with relevant pathogenic mutations.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Neoplasms, Hereditary Nonpolyposis | Colorectal Neoplasm | ONTOLOGY_EXACT | 0.85 |
| Hereditary Breast and Ovarian Cancer Syndrome | — | UNRESOLVED | — |
| Hysterectomy | — | UNRESOLVED | — |
| Ovariectomy | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Follow-up | Other | — | UNRESOLVED |
| salpingo-oophorectomy only by laparoscopy | Procedure | — | UNRESOLVED |
| salpingo-oophorectomy with hysterectomy by laparoscopy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- HBOCS
- description
- For carriers with mutation genes of BRCA1, BRCA2 (both belonging to mutation genes of hereditary breast and ovarian cancer syndrome, HBOCS) and ATM, BRIP1, RAD51, RAD51C, and RAD51D (all belonging to mutation genes of other hereditary ovarian cancer syndrome), if they demand for risk-reducing surgeries, counseling, decision-making analysis, then salpingo-oophorectomy only by laparoscopy and long-term follow-up are provided.
- interventionNames
- Procedure: salpingo-oophorectomy only by laparoscopy
- type
- EXPERIMENTAL
- label
- Lynch syndromes
- description
- for carriers with mutation genes of MLH1, MSH2, MSH6, PMS2, EPCAM (all belonging to mutation genes of Lynch syndromes) and STK11, , if they demand for risk-reducing surgeries, counseling, decision-making analysis, then salpingo-oophorectomy with hysterectomy by laparoscopy and long-term follow-up are provided.
- interventionNames
- Procedure: salpingo-oophorectomy with hysterectomy by laparoscopy
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 35 Years
Show eligibility criteria text
Inclusion Criteria: * Carriers with known and definite mutation genes of hereditary ovarian cancer. * With children and without further requirement of pregnancy. * No less than 35 years for carriers with mutation gene of BRCA1. * No less than 40 years for carriers with mutation gene of BRCA2. * No less than 45 years for carriers with mutation genes of BRIP1, RAD51C, RAD51D and RAD51. * No less than 50 years for carriers with mutation genes of ATM, MSH2, MLH1, SH6, PMS2, EPCAM and STK11. Exclusion Criteria: * Without children. * Not reaching appreciate ages. * With contraindications of laparoscopy. * Refusal of risk-reducing surgeries.
References
Publications (0)
Data not yet available